【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 Pathophysiology and Etiology 9
2.2 Epidemiology 11
2.3 Disease Progression 13
2.4 Treatment 15
3 Marketed Products 19
3.1 Hormonal Therapies 19
3.1.1 Zoladex (Goserelin) – AstraZeneca 19
3.1.2 Lupron Depot (Leuprolide acetate) – Abbvie 21
3.1.3 Triptorelin 22
3.1.4 Firmagon (degarelix) – Ferring 22
3.1.5 Casodex (Bicalutamide) 23
3.1.6 Summary 23
3.2 Chemotherapy agents 24
3.2.1 Taxotere (Docetaxel) – Sanofi 24
3.2.2 Jevtana (Cabazitaxel) – Sanofi 25
3.3 Therapeutic Vaccines 26
3.3.1 Provenge (sipuleucel-T) – Dendreon 26
3.4 Targeted therapies (Second Generation Anti-androgens) 27
3.4.1 Zytiga (Abiraterone acetate) – Janssen 27
3.4.2 Xtandi (Enzalutamide) – Astellas/Medivation 27
3.5 Bone Metastasis Treatments 28
3.5.1 Xofigo (Radium 223) – Bayer/Algeta 28
3.5.2 Xgeva (denosumab) – Amgen 29
3.5.3 Zometa (zoledronic acid) – Novartis 29
3.6 Heat Map for Marketed Products 30
4 Prostate Cancer Developmental Pipeline 33
4.1 Overall Pipeline 33
4.2 Mechanisms of Action 35
4.3 Clinical Trials 36
4.3.1 Attrition Rate 36
4.3.2 Enrollment 38
4.3.3 Duration 41
4.4 Key Late-Stage Pipeline Molecules 43
4.4.1 Cometriq (Cabozantinib) – Exelixis 43
4.4.2 OGX-011 (custirsen sodium) – Teva 43
4.4.3 TAK-700 (orteronel) – Takeda 44
4.4.4 ProstAtak (AdvTk+ valcyclovir) – Advantagene 44
4.4.5 ProstVac – Bavarian Nordic 44
4.4.6 Tasquinimod – Active Biotech 45
4.4.7 Yervoy (Ipilimumab) – Bristol-Myers Squibb 46
4.4.8 ARN-509 – Aragon Pharmaceuticals, Johnson and Jonhson 46
5 Market Forecast to 2019 47
5.1 Global 47
5.1.1 Treatment Usage Patterns 47
5.1.2 Market Size 49
5.2 North America 50
5.2.1 US 50
5.2.2 Canada 52
5.3 Five European Markets 54
5.3.1 Treatment Usage Patterns 54
5.3.2 Annual Cost of Therapy 56
5.3.3 Market Size 57
5.4 Japan 58
5.4.1 Treatment Usage Patterns 58
5.4.2 Market Size 59
6 Prostate Cancer Therapeutics: Drivers and Barriers 60
6.1 Drivers 60
6.1.1 Major Unmet Treatment Needs of Late Stage Prostate Cancer Patients 60
6.1.2 Increasing Disease Population 60
6.1.3 New Drugs Entering the Market 60
6.1.4 Rapid and Robust Uptake of Recently Approved High-Cost Therapies 60
6.1.5 Rapid Inflation Rate for Specialty Pharmaceutical Products in the US 60
6.1.6 Market Capture of Previously Untreated Patient Segments 61
6.2 Barriers 61
6.2.1 Uncertain Treatment Algorithm 61
6.2.2 Uptake Limited by High Prices for New Products 61
6.2.3 Patent Expiry of Taxotere 61
6.2.4 Intensifying Competition Acting as a Barrier to Market Capture 61
7 Licensing and Co-development Deals Analysis 62
7.1 Licensing Deals 62
7.1.1 Algeta Enters into Licensing Agreement with Bayer Schering for Xofigo 65
7.1.2 Sanofi-Aventis Enters into a Licensing Agreement with Oxford BioMedica 65
7.1.3 Novacea Enters Into Licensing Agreement With Schering-Plough For Asentar 65
7.1.4 Teva Pharma Enters into a Licensing Agreement with Oncogenex Pharma for OGX-011 65
7.1.5 Hoffman La Roche Enters into a Licensing Agreement with Inovio Pharmaceuticals for Prostate Cancer and Hepatitis B Immunotherapy Products 66
7.1.6 Colby Pharmaceutical Company Enters into a Licensing Agreement with MannKind for Cancer Immunotherapy Products 66
7.1.7 Ipsen Enters into a Licensing Agreement with GTx 66
7.1.8 Protox Therapeutics Enters into a Licensing Agreement with Kissei Pharma 67
7.1.9 AEterna Zentaris Enters Into License And Collaboration Agreement With Nippon Kayaku For Ozarelix 67
7.1.10 Orion Corporation Enters Into Agreement With Indevus Pharmaceuticals 67
7.2 Co-Development Deals 68
7.2.1 Medivation Enters into Co-Development Agreement with Astellas Pharma 69
7.2.2 Takeda Pharma Enters into an Agreement with Cell Genesys 69
7.2.3 Active Biotech Enters into Co-Development Agreement with Ipsen 69
8 Appendix 70
8.1 Market Definitions 70
8.2 Abbreviations 70
8.3 Sources 73
8.4 Sources for Marketed Products Heat Map 78
8.5 Scientific Support 78
8.6 Research Methodology 78
8.6.1 Coverage 79
8.6.2 Secondary Research 79
8.6.3 Therapeutic Landscape 79
8.6.4 Epidemiology-Based Forecasting 80
8.6.5 Market Size by Geography 81
8.6.6 Geographical Landscape 82
8.6.7 Pipeline Analysis 82
8.6.8 Competitive Landscape 82
8.6.9 Expert Panel Validation 82
8.7 All Publicly Announced Pipeline Products, by Phase 83
8.7.1 Discovery 83
8.7.2 Preclinical/IND-Filed 85
8.7.3 Phase I 94
8.7.4 Phase II 97
8.7.5 Phase III/Pre-Registration 101
8.7.6 Undisclosed Stage of Development 103
8.8 Tabular Forecast Data 103
8.8.1 Global 103
8.8.2 US 104
8.8.3 UK 104
8.8.4 France 105
8.8.5 Germany 105
8.8.6 Italy 106
8.8.7 Spain 106
8.8.8 Japan 107
8.8.9 Canada 107
8.9 Disclaimer 107
【レポート販売概要】
■ タイトル：Prostate Cancer Therapeutics Market to 2019 – Rising Prevalence and Strong Uptake of Recent Approvals to Drive Robust Growth to 2019■ 発行日：2013年11月20日
■ 調査会社：GBI Research
■ 商品コード：GBIR403170041
■ 調査対象地域：グローバル
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