Multiple Sclerosis Therapeutics to 2019 – Treatment Diversification, Increasing Efficacy, and Pipeline Innovation Combine to Drive Growth...市場調査レポートについてご紹介

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【レポートの概要(一部)】

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 7
2 Introduction 8
2.1 Disease Overview 8
2.2 Epidemiology 8
2.3 Symptoms 9
2.4 Etiology 9
2.5 Pathophysiology 10
2.5.1 Blood Brain Barrier Degradation 10
2.5.2 Cellular Infiltration of the Central Nervous System 10
2.6 Co-morbidities/Complications 11
2.7 Diagnosis 12
2.7.1 McDonald Criteria 12
2.7.2 Physical Examination 13
2.7.3 MRI Scans 13
2.7.4 Lumbar Puncture 13
2.7.5 Other Diagnostic Tests 13
2.8 Prognosis 14
2.9 Treatment Efficacy 15
2.10 Treatment Options 15
2.10.1 Corticosteroids 16
2.10.2 Anti-neoplastic Drugs 16
2.10.3 Skeletal Muscle Relaxants 16
2.10.4 Pain Management in MS 17
2.11 Treatment Algorithm 17
2.12 Non-pharmacological Therapies 19
3 Therapeutic Landscape 20
3.1 Copaxone (glatiramer acetate) – Teva Pharmaceuticals 20
3.2 Betaseron (interferon beta 1b) – Bayer AG 21
3.3 Avonex (interferon beta 1a IM) – Biogen 22
3.4 Rebif (interferon beta 1a SC) – Merck Serono 23
3.5 Tysabri (natalizumab) – Biogen Idec/Elan Corporation 24
3.6 Gilenya (fingolimod hydrochloride) – Mitsubishi Tanabe and Novartis 25
3.7 Aubagio (Teriflunomide) – Genzyme Corporation and Sanofi-Aventis 26
3.8 Novantrone (mitoxantrone ) – Merck Serono 26
3.9 Conclusion 28
3.10 Unmet Need 28
4 Pipeline for Multiple Sclerosis Therapeutics 29
4.1 Overall Pipeline 29
4.2 Route of Administration 31
4.3 Molecular Targets within the MS Pipeline 32
4.4 Clinical Trials 34
4.4.1 Failure Rate of Developmental Programs 34
4.4.2 Clinical Trial Size 36
4.4.3 Clinical Trial Duration 38
4.5 Promising Pipeline Candidates 40
4.5.1 Lemtrada (alemtuzumab) – Genzyme and Bayer Schering Pharma 40
4.5.2 Tecfidera (dimethyl fumarate) – Biogen Idec 40
4.5.3 Laquinimod (laquinimod sodium) – Teva Pharmaceuticals 41
4.5.4 ocrelizumab – F. Hoffman-La Roche 42
4.5.5 daclizumab – Biogen Idec and Abbot Laboratories 42
4.5.6 firategrast – GlaxoSmithKline 43
4.5.7 Siponimod (BAF-312) – Novartis AG 44
4.6 Conclusion 44
5 Market Forecast to 2019 47
5.1 Geographical Markets 47
5.1.1 Key Developed Markets 47
5.1.2 US 50
5.1.3 Top Five EU Countries 52
5.1.4 Japan 56
5.2 Drivers and Barriers 58
5.2.1 Drivers 58
5.2.2 Barriers 59
6 Deals and Strategic Consolidations 61
6.1 Major Co-development Deals 61
6.1.1 Daiichi Sankyo Enters into an Agreement with Amplimmune 63
6.1.2 Karo Bio Enters into an Agreement with Pfizer 63
6.1.3 Proteostasis Enters into an Agreement with Elan 63
6.1.4 Lycera Enters into an Agreement with Merck 64
6.1.5 Facet Enters into an Agreement with Trubion 64
6.1.6 UCB Enters into an Agreement with Biogen 64
6.2 Major Licensing Deals 65
6.2.1 Addex Extends its Licensing Agreement with Merck 68
6.2.2 Biogen Enters into a Licensing Agreement with Acorda Therapeutics 69
6.2.3 Genzyme Enters into a Licensing Agreement with Bayer Healthcare 69
6.2.4 Novartis Enters into a Licensing Agreement with Peptimmune 69
6.2.5 Merck Serono Enters into a Licensing Agreement with Apitope Technology 69
6.2.6 Antisense Enters into a Licensing Agreement with Teva Pharmaceutical 70
6.2.7 BioMS Medical Corp Enters into a Licensing Agreement with Eli Lilly 70
6.2.8 Biotica Enters into an Agreement with Wyeth 70
7 Appendix 71
7.1 Pipeline Product Tables by Phase 71
7.2 Market Forecasting Data Tables to 2019 81
7.3 Market Definition 85
7.4 Abbreviations 85
7.5 References 86
7.6 Methodology 89
7.7 Secondary Research 90
7.8 Therapeutic Landscape 90
7.9 Epidemiology-Based Forecasting 91
7.10 Market Size by Geography 92
7.11 Pipeline Analysis 93
7.12 Contact Us 93
7.13 Disclaimer 93


【レポート販売概要】

■ タイトル:Multiple Sclerosis Therapeutics to 2019 – Treatment Diversification, Increasing Efficacy, and Pipeline Innovation Combine to Drive Growth
■ 発行日:2013年7月31日
■ 調査会社:GBI Research
■ 商品コード:GBIR403170031
■ 調査対象地域:グローバル
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