【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 12
1.2 List of Figures 14
2 Introduction 15
2.1 Catalyst 15
2.2 Upcoming Related Reports 15
3 Disease Overview 16
3.1 Etiology and Pathophysiology 17
3.2 Symptoms 23
3.2.1 Prognosis and Diagnosis 24
3.2.2 Quality of Life 27
4 Epidemiology 28
4.1 Risk Factors and Comorbidities 28
4.2 Global Trends 30
4.2.1 US 30
4.2.2 5EU 31
4.2.3 Japan 33
4.3 Forecast Methodology 33
4.3.1 Sources Used 34
4.3.2 Sources Not Used 37
4.3.3 Forecast Assumptions and Methods, Incident Cases 38
4.4 Epidemiological Forecast for ALS (2013-2023) 41
4.4.1 Diagnosed Prevalent Cases of ALS 41
4.4.2 Age-Specific Incident Cases of ALS 42
4.4.3 Sex-Specific Diagnosed Prevalent Cases of ALS 44
4.4.4 Age-Standardized Diagnosed Prevalence of ALS 46
4.5 Discussion 48
4.5.1 Epidemiological Forecast Insight 48
4.5.2 Limitations of the Analysis 48
4.5.3 Strengths of the Analysis 49
5 Current Treatment Options 50
5.1 Overview 50
5.2 Product Profiles – Major Brands 53
5.2.1 Rilutek (riluzole) 53
6 Unmet Needs Assessment and Opportunity Analysis 57
6.1 Overview 57
6.2 Unmet Needs Analysis 59
6.2.1 Therapies That Can Slow or Halt Disease Progression 59
6.2.2 Appetite-Stimulating Agents 59
6.2.3 Preservation of Muscle Strength/Mobility 60
6.2.4 Biomarkers for Diagnosis/Staging 60
6.2.5 Treatments for Sialorrhea 61
6.2.6 Protection of Cognitive Function 62
6.2.7 Relief of Spasticity, Cramps, and Pain 63
6.2.8 Extending Patient Survival 63
6.2.9 Increasing Patient Function 63
7 Research and Development Strategies 65
7.1 Overview 65
7.1.1 Anti-Glutamate Agents 65
7.1.2 Antioxidants and Mitochondrial Preservation 67
7.1.3 Growth Factors 67
7.1.4 Anti-Apoptosis 68
7.1.5 Immunosuppression 69
7.1.6 Protein Aggregation 70
7.2 Clinical Trial Design 71
8 Pipeline Assessment 73
8.1 Overview 73
8.2 Drugs in Late-Stage Clinical Development 73
8.2.1 AB-1010 (masitinib) 74
8.2.2 Radicut (edaravone) 77
8.2.3 Methycobal (mecobalamin) 80
8.2.4 Arimoclomol 82
8.2.5 CK-2017357 (CK-357, tirasemtiv) 84
8.3 Innovative Early-Stage Approaches 88
9 Pipeline Valuation Analysis 90
9.1 Clinical Benchmarks of Key Pipeline Drugs 91
9.2 Commercial Benchmarks of Key Pipeline Drugs 93
9.3 Competitive Assessment 94
9.4 Top-Line Five-Year Forecast 96
9.4.1 US 98
9.4.2 5EU 99
9.4.3 Japan 100
10 Appendix 103
10.1 Bibliography 103
10.2 Abbreviations 118
10.3 Methodology 122
10.4 Forecast Methodology 122
10.4.1 Diagnosed and Treated ALS Patients 124
10.4.2 Launch and Patent Expiry Dates 124
10.4.3 General Pricing Assumptions 125
10.4.4 Individual Drug Assumptions 126
10.4.5 Generic Erosion 128
10.4.6 Pricing of Pipeline Agents 129
10.5 Physicians and Specialists Included in This Study 130
10.6 About the Authors 131
10.6.1 Author 131
10.6.2 Epidemiologist 132
10.6.3 Global Head of Healthcare 132
10.7 About GlobalData 133
10.8 Disclaimer 133
【レポート販売概要】
■ タイトル:筋萎縮性側索硬化症(ALS):グローバル製薬市場機会分析と予測■ 英文:OpportunityAnalyzer: Amyotrophic Lateral Sclerosis (ALS) - Opportunity Analysis and Forecasts to 2018
■ 発行日:2014年6月20日
■ 調査会社:GlobalData
■ 商品コード:GDHC019POA
■ 調査対象地域:グローバル
- 空港スマート照明の世界市場About Airport Smart LightingAirport smart lighting comprises sensor-based lightings systems installed in airside or landside space of airports. It plays a vital role in increasing the operational efficiency of an airport and has a substantial impact on energy savings and improving customer experience. Technavio’s analysts forecast the global airport smart lighting market to grow at a CAGR of 6.81% …
- 血管閉鎖装置(VCD)の世界市場の予測&動向分析:製品別(アクティブ近似器、縫合ベースデバイス、クリップベースデバイス、受動近似器、コラーゲンプラグ、シーラント/ゲルベースデバイス、圧縮補助デバイス、外部止血デバイス)、エンドユーザー別(急性ケア施設、病院、診療所)、セグメント予測、2013-2024Global vascular closure devices (VCDs) market is anticipated to reach USD 1.3 billion by 2024, according to a new report by Grand View Research, Inc. Growing popularity of femoral artery cardiac catheterization and high success rate of VCDs for improved patient comfort and shortening of hemostasis time are potential factors for the projected growth of VCDs market over the forecast period. Adoption …
- 一斉通知システムの世界市場予測(~2024年)The global Mass Notification Systems (MNS) market size is expected to grow from USD 7.3 billion in 2019 to USD 17.3 billion by 2024, at a CAGR of 18.8% during the forecast periodThe growing concern for public safety and security and the increasing implementation of Internet Protocol (IP)-based notification devices are the major factors driving the growth of the MNS market. In-building segment, by …
- デジタルPCR(dPCR)及び定量PCR(qPCR)の世界市場:装置、試薬、ソフトウェアThe global qPCR and dPCR market is expected to reach USD 4.94 Billion by 2021 from USD 3.28 Billion in 2016, growing at a CAGR of 8.5% from 2016 to 2021. Digital PCR Market growth can be attributed to the rising incidences of infectious diseases and genetic disorders (coupled with growing geriatric population that is at greater risk of target diseases as compared to adults); technological advancem …
- 産業用ボイラーの世界市場2017-2021About Industrial Boilers A boiler is typically a closed vessel and has water stored inside it. In this heating system, a furnace is required to heat the boiler. Fuels such as coal are used to generate the heat. Subsequently, the heated air comes in contact with the vessel and convection takes place, heating the water inside the vessel. The heated water eventually produces steam. Technavio’s analys …
- 天然油ポリオール(NOP)の世界市場分析、製品別(大豆油、ヒマシ油、パーム油、キャノーラ油、ヒマワリ油)、セグメント予測The global natural oil polyols (NOP) market is expected to reach USD 11.30 billion by 2024, according to a new report by Grand View Research, Inc. Growing demand for environment-friendly polymers on account of volatile prices of conventional plastics/polymers is expected to drive global NOP market. Regulatory support in the form of financial incentives from European Commission for the adoption of …
- Chronic Urticaria Or Hives:グローバル臨床試験レビューH1, 2013Chronic Urticaria Or Hives Global Clinical Trials Review, H1, 2013 Summary GlobalData's clinical trial report, “Chronic Urticaria Or Hives Global Clinical Trials Review, H1, 2013" provides data on the Chronic Urticaria Or Hives clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Chronic Urticaria Or Hives. It includes an overview of the t …
- ココナッツウォーターの世界市場2016-2020About Coconut Water Coconut water has emerged as a popular ready-to-drink healthy beverage. Over the last few years, the demand for coconut water has increased significantly, especially in North America and Europe. Coconut water has emerged as a good substitute for carbonated drinks and processed juices, owing to its nutritional and blending capabilities. Technavio’s analysts forecast the global c …
- 単純ヘルペス感染症(Herpes Simplex Infections):治療薬開発パイプライン動向(2015年上半期版)Herpes Simplex Infections - Pipeline Review, H1 2015 Summary Global Markets Direct’s, ‘Herpes Simplex Infections - Pipeline Review, H1 2015’, provides an overview of the Herpes Simplex Infections’s therapeutic pipeline. This report provides comprehensive information on the therapeutic development for Herpes Simplex Infections, complete with comparative analysis at various stages, therapeutics asse …
- 酒石酸の世界市場分析:用途別(食品・飲料、ワイン、医薬品、制酸薬)、セグメント予測、– 2020The global tartaric acid market is expected to reach USD 425 million by 2020. Increasing wine consumption in Asia Pacific and Latin America is expected to remain a key factor driving tartaric acid market growth over the forecast period. Increasing tartaric acid consumption as anti-oxidant and taste enhancer in food products is also expected to have a positive impact on the market growth. Tartaric …
- ウェアラブル拡張現実に関する規制と方針(Regulation and Policy for Wearable Augmented Reality)Progress in wearable technologies for monitoring is driven by the same factors that were behind the transition from desktop computing and communication tools to portable devices providing processing and ubiquitous connectivity. These drivers include substantive changes in key social and economic factors. This transition is fuelled by the enormous technical advances in microelectronics and communic …
- Network-as-a-Service(クラウド式ネットワークサービス)の世界市場予測(~2021年)“Infrastructure component adoption to play a significant role in augmenting the growth prospects in the Network-as-a-Service (NAAS) market”This study has been done on a global level, covering four regions broadly, : North America, Europe, Asia-Pacific (APAC), Middle East & Africa (MEA), and & Latin America, and is projected to grow from USD 1.33 billion in 2016 to USD 9.65 billion by 2021, at a CA …
- 試験・検査・認証(TIC)の世界市場Several factors such as formulation of stringent regulations and standards to ensure products’ quality and safety, outsourcing of TIC services to third party service providers, global trading of products, and implementation of new regulations and standards in agriculture and environmental sectors are driving the testing, inspection, and certification (TIC) market. Some of the major regulatory bodi …
- 日本の分子診断・NAT市場2014This report provides:Five-year sales forecasts for the Japanese Molecular Diagnostics market, including: - Infectious Diseases - & …
- 世界及び中国の電動歯ブラシ市場2015is a professional and deep research report in this field. For overview analysis, the report introduces Power Toothbrush basic information including definition, classification, application, industry chain structure, industry overview, policy analysis, and news analysis, etc. For international and China market analysis, the report analyzes Power Toothbrush markets in China and other countries or reg …