【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 10
1.1 List of Tables 14
1.2 List of Figures 16
2 Introduction 17
2.1 Catalyst 17
2.2 Upcoming Related Reports 18
3 Disease Overview 19
3.1 Etiology and Pathophysiology 20
3.1.1 Etiology 20
3.1.2 Pathophysiology 21
3.2 Symptoms 22
3.3 Prognosis 23
3.4 Quality of Life 23
4 Epidemiology 25
4.1 Disease Background 25
4.2 Risk Factors and Comorbidities 25
4.3 Global Trends 27
4.4 Forecast Methodology 28
4.4.1 Sources Used 29
4.4.2 Sources Not Used 34
4.4.3 Forecast Assumptions and Methods 36
4.5 Epidemiological Forecast for Acromegaly (2013-2023) 46
4.5.1 Diagnosed Prevalent Cases of Acromegaly 46
4.5.2 Age-Specific Diagnosed Prevalent Cases of Acromegaly 48
4.5.3 Sex-Specific Diagnosed Prevalent Cases of Acromegaly 49
4.5.4 Age-Standardized Diagnosed Prevalence of Acromegaly 51
4.6 Epidemiological Forecast for Gigantism (2013-2023) 52
4.6.1 Diagnosed Prevalent Cases of Gigantism 52
4.6.2 Age-Specific Diagnosed Prevalent Cases of Gigantism 54
4.6.3 Sex-Specific Diagnosed Prevalent Cases of Gigantism 55
4.6.4 Age-Standardized Diagnosed Prevalence of Gigantism 57
4.7 Epidemiological Forecast for Acromegaly and Gigantism with Macroadenomas, Microadenomas, and Cases Receiving Any Surgical Treatment (2013-2023) 58
4.7.1 Diagnosed Prevalent Cases of Acromegaly and Gigantism with Macroadenomas 58
4.7.2 Diagnosed Prevalent Cases of Acromegaly and Gigantism with Microadenomas 59
4.7.3 Diagnosed Prevalent Cases of Acromegaly and Gigantism Receiving Any Surgical Treatment 60
4.8 Discussion 61
4.8.1 Epidemiological Forecast Insight 61
4.8.2 Limitations of the Analysis 62
4.8.3 Strengths of the Analysis 63
5 Current Treatment Options 64
5.1 Disease Diagnosis 64
5.2 Criteria for Cure and Treatment Goals 65
5.3 Treatment Overview 65
5.4 Clinical Practice 70
5.5 Product Profiles – Somatostatin Analogs 71
5.5.1 Sandostatin SC and Sandostatin LAR Depot (Octreotide Acetate) 71
5.5.2 Somatuline LA and Somatuline Depot (Lanreotide Acetate) 77
5.6 Product Profile – Growth Hormone Receptor Antagonists 81
5.6.1 Somavert (Pegvisomant) 81
5.7 Product Profiles – Dopamine Agonists 87
5.7.1 Cabergoline and Bromocriptine (Widely Genericized) 87
6 Unmet Needs Assessment and Opportunity Analysis 89
6.1 Overview 89
6.2 Improved Efficacy and Safety 90
6.2.1 Unmet Needs 90
6.2.2 Gap Analysis 91
6.2.3 Opportunity 92
6.3 Treatment of Comorbidities 92
6.3.1 Unmet Needs 92
6.3.2 Gap Analysis 93
6.3.3 Opportunity 94
6.4 Physician and Patient Education 94
6.4.1 Unmet Needs 94
6.4.2 Gap Analysis 95
6.4.3 Opportunity Analysis 96
6.5 Improvement in Assay Standardization 96
6.5.1 Unmet Needs 96
6.5.2 Gap Analysis 97
6.5.3 Opportunity Analysis 98
7 R&D Strategies 99
7.1 Overview 99
7.1.1 Targeting Refractory Patients by Improving Existing Drug Classes 99
7.1.2 Novel Drug Delivery Strategies 100
7.1.3 Reformulation Strategies to Reduce Dosing Frequency 101
7.1.4 Licensing and Acquisitions 102
7.2 Clinical Trial Design 102
7.2.1 Current Clinical Trial Design 103
7.2.2 Future Clinical Trial Design 105
8 Pipeline Assessment 106
8.1 Overview 106
8.2 Promising Drugs in Clinical Development 107
8.2.1 Signifor LAR (Pasireotide) 108
8.2.2 Oral Octreotide (Octreotide Acetate) 112
8.2.3 ATL1103 117
8.3 Other Phase III Trials 120
8.4 Innovative Early-Stage Approaches 121
9 Pipeline Valuation Analysis 124
9.1 Clinical Benchmark of Key Pipeline Drugs 124
9.2 Commercial Benchmark of Key Pipeline Drugs 125
9.3 Competitive Assessment 126
9.4 Top-Line Five-Year Forecast 129
9.4.1 US 133
9.4.2 5EU 134
10 Appendix 136
10.1 Bibliography 136
10.2 Abbreviations 146
10.3 Methodology 149
10.4 Forecasting Methodology 149
10.4.1 Diagnosed Acromegaly and Gigantism Patients 149
10.4.2 Percent of Drug-Treated Patients 150
10.4.3 Drugs Included in Each Therapeutic Class 150
10.4.4 Launch and Patent Expiry Dates 150
10.4.5 General Pricing Assumptions 151
10.4.6 Individual Drug Assumptions 152
10.4.7 Generic Erosion 154
10.4.8 Pricing of Pipeline Agents 155
10.5 Physicians and Specialists Included in this Study 156
10.6 About the Authors 157
10.6.1 Analyst 157
10.6.2 Epidemiologist 157
10.6.3 Therapy Director – CVMD 158
10.6.4 Global Head of Healthcare 158
10.7 About GlobalData 159
10.8 Disclaimer 159
【レポート販売概要】
■ タイトル：先端巨大症/巨人症治療薬の世界市場機会分析■ 英文：OpportunityAnalyzer: Acromegaly and Gigantism - Opportunity Analysis and Forecast to 2018
■ 発行日：2014年12月31日
■ 調査会社：GlobalData
■ 商品コード：GDHC028POA
■ 調査対象地域：グローバル
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