【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 13
1.2 List of Figures 15
2 Introduction 16
2.1 Catalyst 16
2.2 Related Reports 16
2.3 Upcoming Related Reports 16
3 Disease Overview 17
3.1 Etiology and Pathophysiology 17
3.1.1 Etiology 17
3.1.2 Pathophysiology 18
3.1.3 Clinical Staging 19
3.1.4 Prognosis 22
3.1.5 Quality of Life 23
3.1.6 Symptoms 24
3.1.7 Diagnosis 24
4 Epidemiology 26
4.1 Disease Background 26
4.2 Risk Factors and Comorbidities 26
4.2.1 Smoking is the most significant risk factor for bladder cancer 27
4.2.2 Up to 25% of male bladder cancer cases are due to occupational exposure to aromatic amines 28
4.3 Global Trends 29
4.3.1 Incidence, Mortality, and Five-Year Prevalence 30
4.3.2 Relative Survival 32
4.3.3 Disability-Adjusted Life Years (DALYs) and Years of Life Lost (YLLs) 33
4.4 Forecast Methodology 34
4.4.1 Sources Used 34
4.4.2 Sources Not Used 36
4.4.3 Forecast Assumptions and Methods 37
4.5 Epidemiological Forecast for Bladder Cancer (2012-2022) 38
4.5.1 Incident Cases of Bladder Cancer 38
4.5.2 Age-Specific Incident Cases of Bladder Cancer 40
4.5.3 Sex-Specific Incident Cases of Bladder Cancer 41
4.5.4 Age-Standardized Incidence Rates of Bladder Cancer 43
4.5.5 Incident Cases of Bladder Cancer by Stage at Diagnosis 44
4.5.6 Five-Year Prevalent Cases of Bladder Cancer 45
4.6 Discussion 47
4.6.1 Epidemiological Forecast Insight 47
4.6.2 Limitations of the Analysis 47
4.6.3 Strengths of the Analysis 48
5 Current Treatment Options 49
5.1 Overview 49
5.2 Product Profiles – Major Brands 50
5.2.1 Valstar (valrubicin) 50
5.2.2 Javlor (vinflunine ditartrate) 54
5.2.3 Intravesical Bacillus Calmette-Guérin (BCG) 58
5.2.4 Mitomycin C 60
5.2.5 GemCis 62
6 Unmet Needs Assessment and Opportunity Analysis 64
6.1 Overview 64
6.2 Unmet Needs Analysis 66
6.2.1 Unmet Need: Better Cure Rate for Patients with NMIBC 66
6.2.2 Unmet Need: Therapies that Prevent Disease Progression in Patients with NMIBC 67
6.2.3 Unmet Need: More Efficacious Therapies for Muscle-Invasive and Metastatic Bladder Cancer 68
6.2.4 Unmet Need: Treatment Options for Platinum-Refractory/Intolerant Metastatic Patients 69
6.2.5 Unmet Need: Lack of Predictive Biomarkers 69
6.2.6 Unmet Need: Better Initial Diagnosis and Resection Success Rates 70
6.3 Opportunity Analysis 71
6.3.1 Opportunity: Replacement for BCG Therapy in NMIBC Setting 71
6.3.2 Opportunity: Salvage Therapy after BCG Failure in High-Grade Patients 71
6.3.3 Opportunity: Redefining the Standard of Care for First-Line Muscle-Invasive and Metastatic Patients 72
6.3.4 Opportunity: Novel Treatments for Platinum-Refractory Patients 73
6.3.5 Opportunity: Leveraging the Immune System to Fight Bladder Cancer 73
6.3.6 Opportunity: Identification of Predictive Biomarkers 73
6.3.7 Opportunity: Neoadjuvant Therapy 74
7 R&D Strategies 75
7.1 Overview 75
7.1.1 Drug Development Dominated by Small Pharmaceutical Companies 75
7.1.2 Large Pharmaceutical Company and Academic Group Cooperation 76
7.1.3 Companies Primarily Focus on the NMIBC Segment 77
7.1.4 Success of BCG Therapy Is a Signal for Further Immunotherapy Strategies 78
7.1.5 Intravesicular Approaches for NMIBC Are Still Strategically Relevant 78
7.2 Clinical Trial Design 79
7.2.1 Registration Studies: Moving Towards More Robust Design 79
7.2.2 No Treatment Options Solid Enough to Constitute a Standard Comparative Arm 80
7.2.3 Variety of the Endpoints Used in Metastatic and NMIBC Settings 81
7.2.4 Contribution of Investigator-Initiated Trials to the Development of Treatment Algorithms 82
8 Pipeline Assessment 85
8.1 Overview 85
8.2 Promising Drugs in Clinical Development 86
8.2.1 EOquin (Apaziquone) 87
8.2.2 Jevtana (cabazitaxel) 90
8.2.3 CG-0070 94
8.2.4 Apatorsen (OGX-427) 98
8.2.5 Abraxane (nab-paclitaxel) 102
8.3 Innovative Early-Stage Approaches 106
8.3.1 Immunotherapies 107
8.3.2 Targeted Therapies 111
9 Pipeline Valuation Analysis 114
9.1 Clinical Benchmark of Key Pipeline Drugs 115
9.2 Commercial Benchmark of Key Pipeline Drugs 119
9.3 Competitive Assessment 122
9.4 Top-Line Five-Year Forecast 123
9.4.1 US 126
9.4.2 5EU 127
10 Appendix 128
10.1 Bibliography 128
10.2 Abbreviations 145
10.3 Methodology 147
10.4 Forecasting Methodology 147
10.4.1 Diagnosed Bladder Cancer Patients 147
10.4.2 Percent Drug-Treated Patients 148
10.4.3 Drugs Included in Each Therapeutic Class 148
10.4.4 Launch Dates 148
10.4.5 General Pricing Assumptions 149
10.4.6 Individual Drug Assumptions 150
10.4.7 Generic Erosion 152
10.5 Physicians and Specialists Included in this Study 153
10.6 About the Authors 154
10.6.1 Authors 154
10.6.2 Epidemiologist 155
10.6.3 Global Head of Healthcare 156
10.7 About GlobalData 157
10.8 Disclaimer 157
【レポート販売概要】
■ タイトル:膀胱癌:市場分析及び予測(~2017)■ 英文:OpportunityAnalyzer: Bladder Cancer - Opportunity Analysis and Forecasts to 2017
■ 発行日:2013年12月31日
■ 調査会社:GlobalData
■ 商品コード:GDATA403163445
■ 調査対象地域:グローバル
- 麻薬スキャナーの世界市場2017-2021About Narcotics Scanner Narcotics are drugs that have several medicinal uses such as severe pain control, anxiety relief, sleep induction, and numbing the senses. However, narcotics are also abused as drugs when taken without the prescription of a physician. These are the non-medicinal uses of narcotics. Narcotics are often smuggled, and this has paved way for the narcotics drug trade. The traffic …
- 農業用微量栄養素の世界市場:亜鉛、ホウ素、銅、マンガン、モリブデン、鉄The market size is projected to reach USD 8.05 Billion by 2021, growing at a CAGR of around 8.2% from 2016. The global agricultural micronutrients market has grown exponentially in the last few years. Countries in the Asia-Pacific region such as China, Japan, and India are the primary targets of the industry. Increase in soil deficiencies, macronutrients antagonism, and increasing demand for of hi …
- 物理療法の世界市場About PhysiotherapyPhysiotherapy is a nonsurgical treatment method, where the treatment for impairments such as injury, deformity, and recovery from surgery is done through physical medicine and therapies, such as heat therapy, cryotherapy, hydrotherapy, and therapeutic exercise. Technavio’s analysts forecast the global Physiotherapy market to grow at a CAGR of 6.42% during the period 2017-2021. [ …
- 次世代シーケンシング(NGS)の世界市場:製品別(消耗品、プラットフォーム、およびサービス)、用途別(バイオマーカー・がん、診断、リプロダクティブヘルス、個別化医療、農業・動物研究、およびその他のアプリケーション)、技術別(合成シーケンス、イオン半導体シーケンス、ライゲーションシーケンス、パイロシーケンシング、単一分子リアルタイムシーケンス、およびその他の技術)、エンドユーザー別(学術・臨床研究センター、製薬・バイオテクノロジー企業、病院・診療所、その他のエンドユーザー)The global next generation sequencing market size was valued at $4,533 million in 2018, and is estimated to reach $18,565 million by 2026, growing at a CAGR of 19.2% from 2019 to 2026. Next generation sequencing (NGS) is a novel procedure for sequencing genomes at low costs and high speed with improved efficiency. NGS also known as deep sequencing and parallel sequencing is a technology that has r …
- オフショア支援船(OSV)の世界市場予測(~2022)The global offshore support vessel market is projected to grow at a CAGR of 4.92%, from 2017 to 2022, to reach a market size of USD 20.15 Billion by 2022. This growth is attributed to increasing focus on oil & gas production at offshore fields, particularly activities in deepwater reserves. The report segments the offshore support vessel market, on the basis of type, into anchor handling tug suppl …
- オンライン映画チケットサービスの世界市場2015-2019About Online Movie Ticketing Service Online movie ticketing service refers to booking movie tickets online using devices such as smartphones, tablets, laptops, and PCs. It is aimed at providing customers with the convenience of booking movie tickets anytime and from anywhere using the Internet. Websites and free mobile apps provided by service providers enable users to book the seats of their choi …
- 過活動膀胱治療法の世界市場2019-2023Global Overactive Bladder Therapeutics Market: About this market Technavio’s overactive bladder (OAB) therapeutics market analysis considers sales from anticholinergics. Beta-3 adrenergic agonists, and other OAB therapeutics. Our analysis also considers the sales of overactive bladder therapeutics in Asia, Europe, North America, and ROW. In 2018, the anticholinergics segment had a significant mark …
- PET 包装の世界市場2016-2020About PET Packaging Many new trends have emerged in the market such as the availability of hot-filling products in PET bottles and aseptic cold-filling PET bottles, which increase the shelf life of the products even if they are not kept at the optimum conditions. Recycling PET for re-use after sorting, cleaning, and transforming PET containers is also becoming popular in the market. Technavio’s an …
- ウルトラピュア硫酸の世界市場(~2019)The ultra pure sulfuric acid (UPS) market was valued at $203.8 million in 2013, with the highest share held by Asia-Pacific accounted for 53%. The global market is projected to grow at a CAGR of 6.1% between 2014 and 2019. The highest investment is forecasted to be in Asia-Pacific, due to the growing applications, low cost of production, and availability of raw materials especially in China, South …
- 加入者データ管理市場(The Subscriber Data Management (SDM) Market: 2012 – 2016)Subscriber data is a principal asset held by network carriers. Subscriber Data Management (SDM) allows carriers to consolidate and manage their cross domain subscriber data encompassing access preferences, authentication, services, identities, location, and presence into unified data repositories. Besides enabling considerable OPEX reductions and allowing carriers to deliver more personalised serv …
- Husky Energy Inc.:石油・ガスの開発・生産動向及びコスト分析- Q2, 2013Husky Energy Inc. Oil & Gas Exploration and Production Operations and Cost Analysis - Q2, 2013 Summary Husky Energy Inc. Oil & Gas Exploration and Production Operations and Cost Analysis is the latest report from GlobalData, the industry analysis specialists, that offers comprehensive information on the operational and financial performance of the company. The report is an essential source for key …
- 垂直産業市場におけるグーグル:Google in Industry VerticalsGoogle has decided several years ago to expand outside search, and even the Internet industry as a whole, and to expand into many new different business areas. Many of these business areas are within the ICT or telecom realm but several go beyond the obvious. Google has supported a business development strategy to achieve the expansion based on industry verticals. The main strategy of Google in in …
- 絶縁の世界市場分析:製品別(ガラス繊維、発泡プラスチック、ミネラルウール)、用途別(住宅建設、工業用、HVACおよびOEM、非住宅建設)、セグメント予測、2014-2025The global insulation market is expected to reach USD 93.34 billion by 2024, according to a new report by Grand View Research, Inc. Rising importance of energy efficient buildings owing to escalating energy costs is expected to remain a key driving factor for global insulation market. Legislative frameworks such as new building codes by the European Union, energy efficiency improvement program by …
- 溶融塩熱エネルギー貯蔵の世界市場2019-2023About this market In the commercial and industrial (C&I) sectors, downtime caused by power outages leads to huge losses for the companies. For commercial and industrial sectors, such as the manufacturing, engineering and construction, pharmaceutical and healthcare, oil and gas, industrial farming, mining, energy, aerospace, petrochemical, warehousing, and distribution sectors, power backup is cruc …
- 世界の熱可塑性プラスチック管市場2015The Global Thermoplastic Pipe Industry Report 2015 is a professional and in-depth study on the current state of the Thermoplastic Pipe industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Thermoplastic Pipe market analysis is provided for the international markets including development trends, competiti …