【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 9
1.1 List of Tables 13
1.2 List of Figures 15
2 Introduction 16
2.1 Catalyst 16
2.2 Related Reports 17
2.3 Upcoming Related Reports 17
3 Disease Overview 18
3.1 Etiology and Pathophysiology 19
3.1.1 Etiology 19
3.1.2 Pathophysiology 20
3.2 Prognosis 21
3.3 Clinical Staging 21
3.4 Symptoms 25
4 Epidemiology 26
4.1 Disease Overview 26
4.2 Risk Factors and Comorbidities 26
4.2.1 The risk of developing pancreatic cancer increases with age 27
4.2.2 Tobacco smokers have a two-fold increased risk of pancreatic cancer 27
4.2.3 Diabetes and obesity increase the risk of developing pancreatic cancer 27
4.2.4 At least 10% of pancreatic cancer cases result from a hereditary predisposition 28
4.3 Global Trends 29
4.3.1 United States 29
4.3.2 France 30
4.3.3 Germany 31
4.3.4 Italy 32
4.3.5 Spain 33
4.3.6 United Kingdom 34
4.4 Forecast Methodology 35
4.4.1 Sources Used 36
4.4.2 Forecast Assumptions and Methods 38
4.4.3 Sources Not Used 40
4.5 Epidemiology Forecast 40
4.5.1 Incident Cases of Pancreatic Cancer 40
4.5.2 Total Five-Year Prevalent Cases of Pancreatic Cancer 47
4.6 Discussion 49
4.6.1 Conclusions on Epidemiological Trends 49
4.6.2 Limitations of the Analysis 50
4.6.3 Strengths of the Analysis 50
5 Current Treatment Options 52
5.1 Overview 52
5.2 Product Profiles — Major Brands 55
5.2.1 Abraxane 55
5.2.2 Gemcitabine 59
5.2.3 Tarceva 63
6 Unmet Needs Assessment and Opportunity Analysis 67
6.1 Overview 67
6.2 Unmet Needs Analysis 69
6.2.1 Therapies That Improve Overall Survival Outcomes for Advanced Patients 69
6.2.2 Effective Adjuvant Treatments That Prevent Recurrence of Disease 70
6.2.3 Earlier Diagnosis of Disease 71
6.2.4 Discovery of Predictive Biomarkers and Understanding of Underlying Causes of Disease 71
6.2.5 Treatment Options for Gemcitabine-Refractory Metastatic Patients 72
6.3 Opportunity Analysis 73
6.3.1 Predictive Biomarker-Driven Targeted Therapies in Combination with Chemotherapy Regimens 73
6.3.2 Treatment for Patients with Early-Stage, Localized Pancreatic Cancer 74
6.3.3 Target Patients with Poor Performance Status 75
6.3.4 Effective Drug Delivery 76
6.3.5 Establish New Chemotherapy to be Standard-of-Care Cytotoxic 77
6.3.6 Development of New Standard of Care for Gemcitabine-Refractory Advanced Patients 78
7 Research and Development Strategies 79
7.1 Overview 79
7.1.1 Reformulation strategies 79
7.1.2 Small/Medium-Sized Pharmaceutical Companies Driving R&D 80
7.1.3 Large Pharmaceutical Companies Betting On Targeted Drug Approaches 81
7.2 Clinical Trial Design 82
7.2.1 Overview 82
7.2.2 Overall Survival is the Primary Endpoint of Choice in Both Adjuvant and Metastatic Trials 85
7.2.3 The Majority of Metastatic Trials Are in Second-Line and Later Patients 86
7.2.4 Gemcitabine: Backbone Therapy and Standard Active Comparator for First-Line Metastatic Trials 87
8 Pipeline Assessment 89
8.1 Overview 89
8.2 Promising Drugs in Clinical Development 91
8.2.1 Algenpantucel-L 92
8.2.2 TH-302 96
8.2.3 Lipoplatin 101
8.2.4 MM-398 104
8.2.5 Glufosfamide 109
8.2.6 90Y-Clivatuzumab Tetraxetan 112
8.3 Innovative Early-Stage Approaches 116
8.3.1 Vaccine and Immunotherapy Combination 118
8.3.2 JAK Inhibition 119
8.3.3 Dual MEK/PI3K inhibition 120
8.3.4 Cancer Stem Cell Targeting 123
8.3.5 Poly (ADP-Ribose) Polymerase Inhibitors 125
8.3.6 Drug Delivery Mechanisms 126
8.3.7 Hedgehog Pathway 127
9 Pipeline Valuation Analysis 130
9.1 Clinical Benchmarking of Key Pipeline Drugs 131
9.2 Commercial Benchmarking of Key Pipeline Drugs 134
9.3 Competitive Assessment 137
9.4 Top-Line Five-Year Forecast 138
9.5 US 141
9.6 Europe 143
10 Appendix 145
10.1 Bibliography 145
10.2 Abbreviations 163
10.3 Methodology 167
10.4 Forecasting Methodology 167
10.4.1 Diagnosed Pancreatic Cancer Patients 167
10.4.2 Percent Drug-Treated 168
10.4.3 Drugs Included in Each Therapeutic Class 168
10.4.4 Launch and Patent Expiry Dates 168
10.4.5 General Pricing Assumptions 169
10.4.6 Individual Drug Assumptions 170
10.4.7 Generic Erosion 174
10.5 Physicians and Specialists Included in this Study 175
10.6 About the Authors 176
10.6.1 Authors 176
10.6.2 Epidemiologists 177
10.6.3 Global Head of Healthcare 177
10.7 About GlobalData 178
10.8 Disclaimer 178
【レポート販売概要】
■ タイトル:膵癌治療市場機会分析及び予測(~2017)■ 英文:OpportunityAnalyzer: Pancreatic Cancer - Opportunity Analysis and Forecasts to 2017
■ 発行日:2014年3月27日
■ 調査会社:GlobalData
■ 商品コード:GDHC016POA
■ 調査対象地域:グローバル
- 腎細胞癌の疫学的予測EpiCast Report: Renal Cell Carcinoma - Epidemiology Forecast to 2023 Summary Renal cell carcinoma (RCC) is a type of kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport waste molecules from the blood to the urine. RCC is the most common type of kidney cancer in adults, being responsible for approximately 90% of …
- 繊維ガラスフローリングの世界市場分析:用途別(住宅、商業、工業用)、地域別(北アメリカ、ヨーロッパ、APAC、LATAM、MEA)、国別(米国、ドイツ、フランス、中国、ブラジル)、セグメント予測、2014-2025The global fiberglass flooring market is expected to reach USD 987 million by 2025, according to a new report conducted by Grand View Research, Inc. The growing application in industrial, residential and commercial buildings owing to the longer lifespan of floors coupled with better aesthetics will drive growth over the upcoming years. Moreover, the rising demand for residential buildings in light …
- フレキシブルプラスチック包装の世界市場予測(~2022年):ポーチ、袋、ラップ、ロールストック、プレスチックフィルム、紙、アルミ箔、 バイオプラスチック“Growth in demand from the food & beverage industry to drive the market for flexible plastic packaging” The global market for flexible plastic packaging is projected to grow from USD 102.19 billion in 2017 to reach USD 131.65 billion by 2022, at an estimated CAGR of 5.2%. The flexible plastic packaging market is driven by factors such as growth in demand for sustainable packaging, increase in the …
- 醸造用酵素の世界市場予測(~2023年):アミラーゼ、β-グルカナーゼ、プロテアーゼ、キシラナーゼ、ALDC、ペクチナーゼThe brewing enzymes market is estimated at USD 352.1 million in 2018. It is projected to reach USD 484.7 million by 2023, at a CAGR of 6.6% from 2018, in terms of value. The use of enzymes has become increasingly important in the brewing industry, as they accelerate the chemical reaction without a change in their own structure. To enhance the brewing process, commercial exogenous enzymes are used …
- 自動車診断スキャンツールの世界市場予測(~2025年)“Increasing number of automotive service stations and stringent emission norms will likely drive the automotive diagnostic scan tools market”The automotive diagnostic scan tools market is estimated to be USD 37.42 billion in 2018 and is projected to grow at a CAGR of 5.02% during the forecast period, to reach a market size of USD 52.73 billion by 2025. Increase in the number of automotive workshop …
- アメリカの手術ナビゲーションシステム市場2016-2020About Surgical Navigation SystemsSurgical navigation system enhances computer-assisted surgeries by providing image guidance, navigation software, and computational equipment for both preoperative and intraoperative planning and guidance. The primary clinical aim of computer-assisted surgeries is to assist the surgeon in planning and implementing an optimal strategy of surgery, for diagnostic as w …
- 太陽光発電用マイクロインバータ―(ソーラーマイクロインバータ―)の世界市場2018-2022About Solar Microinverter Solar microinverters convert direct current (DC) from solar panels into alternate current (AC) of the required frequency. The output from several microinverters is later combined and fed to electrical grids to generate power. Technavio’s analysts forecast the global solar microinverter market to grow at a CAGR of 15.54% during the period 2018-2022. Covered in this report …
- 膿瘍(Abscess):世界の治験レビュー(2015年上半期版)Abscess Global Clinical Trials Review, H1, 2015 Summary GlobalData's clinical trial report, “Abscess Global Clinical Trials Review, H1, 2015" provides an overview of Abscess clinical trials scenario. This report provides top line data relating to the clinical trials on Abscess. Report includes an overview of trial numbers and their average enrollment in top countries conducted across the globe. Th …
- 食品サービス向けパッケージングの世界市場予測(~2022年)“Food service packaging market projected to grow at a CAGR of 5.23%” The food service packaging market size is projected to grow at a CAGR of 5.23% during the forecast period of 2017–2022, and reach USD 84.33 billion by 2022. Food service packaging is used to package processed and semi-processed food products. The growth in demand from restaurants, fast food joints, takeaway restaurants, quick-ser …
- 慢性ぜんそく(Chronic Asthma):世界の治験レビュー2014年下半期版Chronic Asthma Global Clinical Trials Review, H2, 2014 Summary GlobalData's clinical trial report, “Chronic Asthma Global Clinical Trials Review, H2, 2014" provides data on the Chronic Asthma clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Chronic Asthma. It includes an overview of the trial numbers and their recruitment status as per …
- 製薬用濾過の世界市場予測(~2022):濾過製品(メンブレンフィルター、シングルユース)、濾過技術、用途、規模The global pharmaceutical filtration market is projected to reach USD 22.71 Billion by 2021 from USD 13.73 Billion in 2016, at a CAGR of 10.6% during the forecast period. Growth in the market for pharmaceutical filtration is primarily driven by factors such as growth in the production of biopharmaceuticals, technological advancements in filtration equipment, and rapid growth in generics production …
- 精密林業の世界市場予測(~2024年)Precision forestry market anticipated to grow at CAGR of 9.0% from 2019 to 2024 The precision forestry market was worth USD 3.9 billion in 2019 and is projected to reach USD 6.1 billion by 2024, at a CAGR of 9.0% during 2019–2024. The major factors driving the growth of the precision forestry market are increasing mechanization in emerging countries of Asia Pacific & Africa, rising construction ac …
- ステビアの世界市場2016-2020About Stevia Stevia, also known as stevia rebaudiana, is a natural and calorie-free plant-derived sweetener used as a sugar substitute in food, beverages, and other applications. The stevia plant contains sweet compounds called steviol glycosides. It is 250-300 times sweeter than sugar. Technavio’s analysts forecast the global stevia market to grow at a CAGR of 8.82% during the period 2016-2020. [ …
- イタリアの分子診断・検査市場2014This report provides an overview of the Italian molecular diagnostic testing market, including test volume, and sales forecasts by application, and supplier shares by test.Table of ContentsBusiness Environment Market Structure Market Size, Growth, and Major Suppliers' Market Shares List of TablesMolec …
- 世界の腫瘍溶解性ウイルス治療パイプライン分析Though still in nascent stages, Oncolytic viruses have shown immense opportunities and potential to be tapped in the future to improve the treatment of cancer and the lives of the patients. Immunotherapy, the umbrella for Oncolytic viruses would not offer cures, but survival solutions with significant importance. Also, the side effects of this therapy would be tolerable by the patients, which coul …