PharmaFocus: Vaccine Adjuvants in Infectious Disease...市場調査レポートについてご紹介

【英文タイトル】PharmaFocus: Vaccine Adjuvants in Infectious Disease

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【レポートの概要(一部)】

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 8
1.2 List of Figures 9
2 Introduction 10
2.1 Catalyst 10
3 Vaccines and the Host Immune Response 11
3.1 Vaccines in Infectious Disease 11
3.2 Host Immune Response 12
3.2.1 Primary Barriers Against Infection 12
3.2.2 Innate Immune System 13
3.2.3 Adaptive Immune System 15
3.3 Vaccine Adjuvants 18
3.3.1 Overview 18
3.3.2 Adjuvant Target: Dendritic Cells 19
3.3.3 Adjuvant Target: Toll-Like Receptors 22
3.3.4 Splenic Involvement in Immune Response 25
3.3.5 Antigen-Depot Effect 25
4 Market Drivers and Barriers 27
4.1 Overview 27
4.2 Drivers 28
4.2.1 Driver: Government initiatives to increase vaccination programs 28
4.2.2 Driver: New routes of administration for vaccines 29
4.2.3 Driver: Rapidly mutating pathogens 29
4.2.4 Driver: Recombinant vaccine technology 30
4.2.5 Driver: Increased research efforts against unvaccinated disease 30
4.3 Barriers 31
4.3.1 Barrier: Decreasing or stagnant vaccination rates 31
4.3.2 Barrier: Increasing vaccine prices 32
4.3.3 Barrier: Public opinion of vaccine and adjuvants 33
5 Current Adjuvant Options 34
5.1 Overview 34
5.2 Product Profiles – Major Adjuvant Classes 37
5.2.1 Aluminum Salts (Alum) 37
5.2.2 Emulsions 40
5.2.3 Particulate Delivery Mechanisms 43
5.2.4 Microbial Derivatives 46
5.2.5 Oligonucleotides 49
5.2.6 Adjuvant Systems 52
6 Needs Assessment and Opportunity Analysis 56
6.1 Overview 56
6.2 Unmet Needs Analysis 57
6.2.1 Adjuvant Safety 57
6.2.2 DC Recognition 57
6.2.3 Appropriate TLR Activation 58
6.2.4 Formulation and Dosing 58
6.3 Opportunity Analysis 60
6.3.1 Novel Routes of Administration and Splenic Involvement 60
6.3.2 Combinatorial Adjuvant Systems 61
6.3.3 Limited Use of Antigen Depot 61
7 Clinical Trials and Regulatory Strategy 63
7.1 Clinical Trial Design 63
7.1.1 Non-clinical Evaluation 63
7.1.2 Adjuvant Mechanism of Action Evaluation 64
7.1.3 Clinical Safety Evaluation 64
7.1.4 KOL Opinion on Clinical Design 65
7.2 Regulatory Strategy 67
7.2.1 Overview 67
7.2.2 World Health Organization (WHO) 68
7.2.3 US 69
7.2.4 EU 73
7.2.5 Cultural Differences in Adjuvant Use (US vs. Europe) 73
8 Appendix 75
8.1 Bibliography 75
8.2 Abbreviations 81
8.3 Research Methodology 82
8.4 Physicians and Specialists Included in this Study 83
8.5 About the Authors 85
8.5.1 Author 85
8.5.2 Reviewer 85
8.5.3 Global Head of Healthcare 86
8.6 About GlobalData 86
8.7 Contact Us 86
8.8 Disclaimer 87


【レポート販売概要】

■ タイトル:PharmaFocus: Vaccine Adjuvants in Infectious Disease
■ 英文:PharmaFocus: Vaccine Adjuvants in Infectious Disease
■ 発行日:2013年3月31日
■ 調査会社:GlobalData
■ 商品コード:GDATA403160700
■ 調査対象地域:グローバル
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