【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 10
1.1 List of Tables 16
1.2 List of Figures 21
2 Introduction 23
2.1 Catalyst 23
2.2 Related Reports 24
2.3 Upcoming Related Reports 24
3 Disease Overview 25
3.1 Etiology and Pathophysiology 25
3.1.1 Etiology 25
3.1.2 Pathophysiology 27
3.2 Clinical Staging 28
3.3 Symptoms 29
4 Epidemiology 31
4.1 Disease Background 31
4.2 Risk Factors and Comorbidities 31
4.3 Global Trends 34
4.3.1 8MM, Incidence Trends 34
4.3.2 8MM, Five-Year Relative Survival 36
4.3.3 8MM, Screening Programs for CRC 37
4.4 Forecast Methodology 39
4.4.1 Sources Used 40
4.4.2 Sources Not Used 47
4.4.3 Forecast Assumptions and Methods 48
4.5 Epidemiological Forecast of CRC (2013-2023) 52
4.5.1 Diagnosed Incident Cases of CRC 52
4.5.2 Age-Specific Diagnosed Incident Cases of CRC 54
4.5.3 Sex-Specific Diagnosed Incident Cases of CRC 55
4.5.4 Age-Standardized Incidence 57
4.5.5 Cancer Stage at Diagnosis 58
4.5.6 Diagnosed Five-Year Prevalent Cases of CRC 59
4.5.7 KRAS Status among Diagnosed Five-Year Prevalent Cases of CRC 61
4.6 Discussion 61
4.6.1 Epidemiological Forecast Insight 61
4.6.2 Limitations of the Analysis 63
4.6.3 Strengths of the Analysis 64
5 Disease Management 65
5.1 Diagnosis and Treatment Overview 65
5.1.1 Screening and Diagnosis 65
5.1.2 Treatment Guidelines and Leading Prescribed Drugs 68
5.1.3 Clinical Practice 72
5.2 US 78
5.2.1 Screening and Diagnosis 80
5.2.2 Clinical Practice 81
5.3 France 83
5.3.1 Screening and Diagnosis 85
5.3.2 Clinical Practice 85
5.4 Germany 87
5.4.1 Screening and Diagnosis 89
5.4.2 Clinical Practice 89
5.5 Italy 91
5.5.1 Screening and Diagnosis 93
5.5.2 Clinical Practice 93
5.6 Spain 95
5.6.1 Screening and Diagnosis 97
5.6.2 Clinical Practice 97
5.7 UK 99
5.7.1 Screening and Diagnosis 101
5.7.2 Clinical Practice 101
5.8 Japan 103
5.8.1 Screening and Diagnosis 105
5.8.2 Clinical Practice 105
5.9 China 107
5.9.1 Screening and Diagnosis 108
5.9.2 Clinical Practice 108
6 Competitive Assessment 110
6.1 Overview 110
6.2 Product Profiles — Major Brands 111
6.2.1 Avastin (Bevacizumab) 111
6.2.2 Erbitux (Cetuximab) 117
6.2.3 Vectibix (Panitumumab) 122
6.2.4 Stivarga (Regorafenib) 126
6.2.5 Zaltrap (Ziv-Aflibrcept) 131
6.2.6 Lonsurf (TAS-102) 135
6.2.7 TS-1 (Tegafur, Gimeracil, Oteracil) 140
6.2.8 Xeloda (Capecitabine) 144
7 Unmet Need and Opportunity 148
7.1 Overview 148
7.2 Therapies That Provide Substantial Overall Survival Benefit for Metastatic Patients 149
7.2.1 Unmet Need 149
7.2.2 Gap Analysis 151
7.2.3 Opportunity 151
7.3 Targeted Treatments for KRAS and BRAF Mutaton-Positive Patients 153
7.3.1 Unmet Need 153
7.3.2 Gap Analysis 154
7.3.3 Opportunity 154
7.4 Effective Neoadjuvant/Adjuvant Therapies for High Risk Resectable Disease 155
7.4.1 Unmet Need 155
7.4.2 Gap Analysis 156
7.4.3 Opportunity 156
7.5 Tolerable Later-Line Therapies For Chemotherapy-Resistant Patients 157
7.5.1 Unmet Need 157
7.5.2 Gap Analysis 157
7.5.3 Opportunity 158
8 Pipeline Assessment 159
8.1 Overview 159
8.2 Promising Drugs in Clinical Development 160
8.2.1 Cyramza (Ramucirumab) 161
8.2.2 Imprime PGG 167
8.2.3 MGN1703 173
8.2.4 Nintedanib (BIBF-1120) 179
8.3 Promising Approaches in Early-Stage Development 184
8.3.1 Anti-Angiopoietin-2 Inhibitors 184
8.3.2 Strategies for BRAF Mutation-Positive Disease 186
8.3.3 Strategies for KRAS-Mutation Positive Disease 192
8.3.4 Immune Checkpoint Inhibitors 196
9 Current and Future Players 201
9.1 Overview 201
9.2 Trends in Corporate Strategy 205
9.3 Company Profiles 207
9.3.1 Roche/Genentech 207
9.3.2 Sanofi 211
9.3.3 Eli Lilly and Company 214
9.3.4 Merck KGaA 217
9.3.5 Bayer 220
9.3.6 Taiho Pharmaceutical 223
10 Market Outlook 226
10.1 Global Markets 226
10.1.1 Forecast 226
10.1.2 Drivers and Barriers – Global Issues 230
10.2 United States 233
10.2.1 Forecast 233
10.2.2 Key Events 237
10.2.3 Drivers and Barriers 237
10.3 France 240
10.3.1 Forecast 240
10.3.2 Key Events 244
10.3.3 Drivers and Barriers 244
10.4 Germany 247
10.4.1 Forecast 247
10.4.2 Key Events 251
10.4.3 Drivers and Barriers 251
10.5 Italy 253
10.5.1 Forecast 253
10.5.2 Key Events 257
10.5.3 Drivers and Barriers 257
10.6 Spain 259
10.6.1 Forecast 259
10.6.2 Key Events 263
10.6.3 Drivers and Barriers 263
10.7 United Kingdom 265
10.7.1 Forecast 265
10.7.2 Key Events 269
10.7.3 Drivers and Barriers 269
10.8 Japan 272
10.8.1 Forecast 272
10.8.2 Key Events 276
10.8.3 Drivers and Barriers 276
10.9 China 278
10.9.1 Forecast 278
10.9.2 Key Events 282
10.9.3 Drivers and Barriers 282
11 Appendix 286
11.1 Bibliography 286
11.2 Abbreviations 322
11.3 Methodology 329
11.4 Forecasting Methodology 329
11.4.1 Diagnosed Colorectal Cancer Patients 329
11.4.2 Percent Drug-Treated Patients 330
11.4.3 Drugs Included in Each Therapeutic Class 330
11.4.4 Launch and Patent Expiration Dates 331
11.4.5 General Pricing Assumptions 332
11.4.6 Average Body Weight and Surface Area Across the 8MM 333
11.4.7 Individual Drug Assumptions 333
11.4.8 Generic Erosion 339
11.4.9 Pricing of Pipeline Agents 339
11.5 Primary Research – KOLs Interviewed for this Report 340
11.6 Primary Research – Prescriber Survey 342
11.7 About the Authors 343
11.7.1 Analyst 343
11.7.2 Epidemiologist 343
11.7.3 Global Head of Healthcare 344
11.8 About GlobalData 345
11.9 Disclaimer 345
【レポート販売概要】
■ タイトル：大腸がん（Colorectal Cancer）治療薬の世界市場予測および分析■ 英文：PharmaPoint: Colorectal Cancer - Global Drug Forecast and Market Analysis to 2023
■ 発行日：2014年11月30日
■ 調査会社：GlobalData
■ 商品コード：GDHC95PIDR
■ 調査対象地域：グローバル
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