膀胱癌:市場分析及び予測(~2017)...市場調査レポートについてご紹介

【英文タイトル】OpportunityAnalyzer: Bladder Cancer - Opportunity Analysis and Forecasts to 2017

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【レポートの概要(一部)】

1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 13
1.2 List of Figures 15
2 Introduction 16
2.1 Catalyst 16
2.2 Related Reports 16
2.3 Upcoming Related Reports 16
3 Disease Overview 17
3.1 Etiology and Pathophysiology 17
3.1.1 Etiology 17
3.1.2 Pathophysiology 18
3.1.3 Clinical Staging 19
3.1.4 Prognosis 22
3.1.5 Quality of Life 23
3.1.6 Symptoms 24
3.1.7 Diagnosis 24
4 Epidemiology 26
4.1 Disease Background 26
4.2 Risk Factors and Comorbidities 26
4.2.1 Smoking is the most significant risk factor for bladder cancer 27
4.2.2 Up to 25% of male bladder cancer cases are due to occupational exposure to aromatic amines 28
4.3 Global Trends 29
4.3.1 Incidence, Mortality, and Five-Year Prevalence 30
4.3.2 Relative Survival 32
4.3.3 Disability-Adjusted Life Years (DALYs) and Years of Life Lost (YLLs) 33
4.4 Forecast Methodology 34
4.4.1 Sources Used 34
4.4.2 Sources Not Used 36
4.4.3 Forecast Assumptions and Methods 37
4.5 Epidemiological Forecast for Bladder Cancer (2012-2022) 38
4.5.1 Incident Cases of Bladder Cancer 38
4.5.2 Age-Specific Incident Cases of Bladder Cancer 40
4.5.3 Sex-Specific Incident Cases of Bladder Cancer 41
4.5.4 Age-Standardized Incidence Rates of Bladder Cancer 43
4.5.5 Incident Cases of Bladder Cancer by Stage at Diagnosis 44
4.5.6 Five-Year Prevalent Cases of Bladder Cancer 45
4.6 Discussion 47
4.6.1 Epidemiological Forecast Insight 47
4.6.2 Limitations of the Analysis 47
4.6.3 Strengths of the Analysis 48
5 Current Treatment Options 49
5.1 Overview 49
5.2 Product Profiles – Major Brands 50
5.2.1 Valstar (valrubicin) 50
5.2.2 Javlor (vinflunine ditartrate) 54
5.2.3 Intravesical Bacillus Calmette-Guérin (BCG) 58
5.2.4 Mitomycin C 60
5.2.5 GemCis 62
6 Unmet Needs Assessment and Opportunity Analysis 64
6.1 Overview 64
6.2 Unmet Needs Analysis 66
6.2.1 Unmet Need: Better Cure Rate for Patients with NMIBC 66
6.2.2 Unmet Need: Therapies that Prevent Disease Progression in Patients with NMIBC 67
6.2.3 Unmet Need: More Efficacious Therapies for Muscle-Invasive and Metastatic Bladder Cancer 68
6.2.4 Unmet Need: Treatment Options for Platinum-Refractory/Intolerant Metastatic Patients 69
6.2.5 Unmet Need: Lack of Predictive Biomarkers 69
6.2.6 Unmet Need: Better Initial Diagnosis and Resection Success Rates 70
6.3 Opportunity Analysis 71
6.3.1 Opportunity: Replacement for BCG Therapy in NMIBC Setting 71
6.3.2 Opportunity: Salvage Therapy after BCG Failure in High-Grade Patients 71
6.3.3 Opportunity: Redefining the Standard of Care for First-Line Muscle-Invasive and Metastatic Patients 72
6.3.4 Opportunity: Novel Treatments for Platinum-Refractory Patients 73
6.3.5 Opportunity: Leveraging the Immune System to Fight Bladder Cancer 73
6.3.6 Opportunity: Identification of Predictive Biomarkers 73
6.3.7 Opportunity: Neoadjuvant Therapy 74
7 R&D Strategies 75
7.1 Overview 75
7.1.1 Drug Development Dominated by Small Pharmaceutical Companies 75
7.1.2 Large Pharmaceutical Company and Academic Group Cooperation 76
7.1.3 Companies Primarily Focus on the NMIBC Segment 77
7.1.4 Success of BCG Therapy Is a Signal for Further Immunotherapy Strategies 78
7.1.5 Intravesicular Approaches for NMIBC Are Still Strategically Relevant 78
7.2 Clinical Trial Design 79
7.2.1 Registration Studies: Moving Towards More Robust Design 79
7.2.2 No Treatment Options Solid Enough to Constitute a Standard Comparative Arm 80
7.2.3 Variety of the Endpoints Used in Metastatic and NMIBC Settings 81
7.2.4 Contribution of Investigator-Initiated Trials to the Development of Treatment Algorithms 82
8 Pipeline Assessment 85
8.1 Overview 85
8.2 Promising Drugs in Clinical Development 86
8.2.1 EOquin (Apaziquone) 87
8.2.2 Jevtana (cabazitaxel) 90
8.2.3 CG-0070 94
8.2.4 Apatorsen (OGX-427) 98
8.2.5 Abraxane (nab-paclitaxel) 102
8.3 Innovative Early-Stage Approaches 106
8.3.1 Immunotherapies 107
8.3.2 Targeted Therapies 111
9 Pipeline Valuation Analysis 114
9.1 Clinical Benchmark of Key Pipeline Drugs 115
9.2 Commercial Benchmark of Key Pipeline Drugs 119
9.3 Competitive Assessment 122
9.4 Top-Line Five-Year Forecast 123
9.4.1 US 126
9.4.2 5EU 127
10 Appendix 128
10.1 Bibliography 128
10.2 Abbreviations 145
10.3 Methodology 147
10.4 Forecasting Methodology 147
10.4.1 Diagnosed Bladder Cancer Patients 147
10.4.2 Percent Drug-Treated Patients 148
10.4.3 Drugs Included in Each Therapeutic Class 148
10.4.4 Launch Dates 148
10.4.5 General Pricing Assumptions 149
10.4.6 Individual Drug Assumptions 150
10.4.7 Generic Erosion 152
10.5 Physicians and Specialists Included in this Study 153
10.6 About the Authors 154
10.6.1 Authors 154
10.6.2 Epidemiologist 155
10.6.3 Global Head of Healthcare 156
10.7 About GlobalData 157
10.8 Disclaimer 157


【レポート販売概要】

■ タイトル:膀胱癌:市場分析及び予測(~2017)
■ 英文:OpportunityAnalyzer: Bladder Cancer - Opportunity Analysis and Forecasts to 2017
■ 発行日:2013年12月31日
■ 調査会社:GlobalData
■ 商品コード:GDATA403163445
■ 調査対象地域:グローバル
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