PharmaFocus: HIV – R&D Strategies towards Cure and Prevention...市場調査レポートについてご紹介

【英文タイトル】PharmaFocus: HIV - R&D Strategies towards Cure and Prevention

▼当市場調査レポートの詳細内容確認、お問い合わせ及びご購入申込は下記ページでお願いします。▼マーケットレポート

【レポートの概要(一部)】

1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 11
1.2 List of Figures 12
2 Introduction 13
2.1 Catalyst 13
2.2 Related Reports 14
3 Drivers and Barriers for Non-ART Interventions 15
3.1 Overview 15
3.2 Drivers 16
3.2.1 Driver: Approval of Gilead’s Truvada for PrEP 16
3.2.2 Driver: High Cost and Side Effects of Antiretroviral Therapy 17
3.2.3 Driver: Immunological Non-Responders 18
3.2.4 Driver: Aging Of HIV Patients with Related Comorbidities 18
3.3 Barriers 19
3.3.1 Barrier: Big Pharma Deprioritizes HIV Vaccine Development 19
3.3.2 Barrier: Challenging Uptake of Latency Reversal Agents for Fear of Carcinogenesis 20
3.3.3 Barrier: Difficulty in Recruiting Trial Participants 20
3.3.4 Barrier: High Cost and Risk of Gene Therapy Approaches 21
3.3.5 Barrier: Continuously Improving ART 22
4 Current Treatment Paradigm 23
4.1 Overview 23
4.2 Current Treatment Paradigm 23
4.3 Current Prevention Strategies 25
4.4 Summary and Outlook 27
5 Needs Assessment and Opportunity Analysis 29
5.1 Overview 29
5.2 Unmet Needs 29
5.2.1 Unmet Need: Prophylaxis against HIV 29
5.2.2 Unmet Need: Cure for HIV 30
5.2.3 Unmet Need: Drug Delivery Mechanisms that Reach Viral Reservoirs 31
5.2.4 Unmet Need: New Therapeutic Approaches for Patients Unresponsive to ART 32
5.2.5 Unmet Need: Increased Funding towards Research 33
5.3 Opportunities 34
5.3.1 Opportunity: Novel Approaches to Invigorate the HIV Treatment Algorithm 34
5.3.2 Opportunity: New Generation Combination Therapies to Foster Collaboration 35
5.3.3 Opportunity: Development of Cheap and Direct Diagnostic Tests 36
6 Novel R&D Strategies 37
6.1 Overview 37
6.2 Vaccines 39
6.2.1 Overview 39
6.2.2 Clinical Positioning 43
6.2.3 Categories of Vaccine Technologies 45
6.2.4 Promising Vaccine Regimens 52
6.3 Latency Reversal Agents 64
6.3.1 Overview 64
6.3.2 Clinical Positioning 68
6.3.3 Latency Reversal Agents in Development 69
6.4 Other Approaches 72
6.4.1 Cytokines 72
6.4.2 Genetic Modification of Stem Cells and Autologous Transplantation 75
6.5 Combination Therapies 78
7 Clinical Trial Design 81
7.1 Overview 81
7.2 Clinical Trials by Phase and Therapeutic Approach 82
7.3 Clinical Trial Challenges 86
7.3.1 Preventative Vaccines 86
7.3.2 Therapeutic Vaccines 89
7.3.3 Latency Reversal Agents 91
7.3.4 Gene Therapies 93
8 Appendix 94
8.1 Bibliography 94
8.2 Abbreviations 105
8.3 Methodology 107
8.4 Physicians and Specialists Included in this Study 107
8.4.1 Dr. Thomas Hanke, PhD 107
8.4.2 Dr. Jan van Lunzen, MD 107
8.4.3 Dr. David Margolis, MD 107
8.4.4 Dr. Giuseppe Pantaleo, MD 107
8.5 About the Authors 108
8.5.1 Analyst 108
8.5.2 Director of Infectious Disease and Cardiovascular and Metabolic Disease 108
8.5.3 Global Head of Healthcare 109
8.6 About GlobalData 110
8.7 Disclaimer 110


【レポート販売概要】

■ タイトル:PharmaFocus: HIV – R&D Strategies towards Cure and Prevention
■ 英文:PharmaFocus: HIV - R&D Strategies towards Cure and Prevention
■ 発行日:2013年8月31日
■ 調査会社:GlobalData
■ 商品コード:GDATA403161932
■ 調査対象地域:グローバル
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