【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 6
1.1 List of Tables 9
1.2 List of Figures 10
2 Introduction 12
2.1 Symptoms 12
2.2 Etiology 13
2.3 Pathophysiology 13
2.3.1 Disease Initiation 13
2.3.2 Disease Propagation 14
2.4 Co-Morbidities and Complications 15
2.5 Diagnosis 16
2.5.1 Physical Examination 16
2.5.2 Blood Tests 16
2.5.3 X-Ray Imaging 17
2.6 Classification 17
2.7 Epidemiology 19
2.8 Prognosis and Disease Staging 19
2.9 Measurement of Treatment Effectiveness 20
2.10 Treatment Options 21
2.10.1 Pharmacological 21
2.10.2 Treatment Algorithms and Prescribing Habits 25
2.10.3 Non-Pharmacological Care 28
3 Marketed Products 29
3.1 Therapeutic Landscape 30
3.1.1 Remicade (infliximab) – Johnson and Johnson, Merck 30
3.1.2 Humira (adalimumab) – Abbott Laboratories 32
3.1.3 Enbrel (etanercept) – Amgen Inc., Pfizer Inc. and Takeda Pharmaceutical Co. Ltd. 34
3.1.4 Rituxan (rituximab) – Genentech (Roche Group), Biogen IDEC Inc. 36
3.1.5 Orencia (abatacept) – Bristol-Myers Squibb 38
3.1.6 Actemra (tocilizumab) -F Hoffman La Roche Ltd. 40
3.1.7 Simponi (golimumab) – Johnson and Johnson, Merck 42
3.1.8 Cimzia (certolizumab pegol) – UCB S.A. 43
3.1.9 Remsima (biosimilar infliximab) – Celltrion Inc. 44
3.2 Comparative Efficacy and Safety 44
3.3 Unmet Need 47
4 Pipeline for Rheumatoid Arthritis Monoclonal Antibody Therapeutics 48
4.1 Overall Pipeline 48
4.2 Molecular Targets in the Pipeline 49
4.3 Clinical Trials 52
4.3.1 Failure Rate 52
4.3.2 Patient Enrolment and Clinical Trial Size 56
4.3.3 Duration 59
4.4 Promising Drug Candidates in the Pipeline 61
4.4.1 Arzerra (ofatumumab) – Genmab A/S, GlaxoSmithKline Plc. 61
4.4.2 LY2127399 (tabalumab) – Eli Lily and Company 61
4.4.3 REGN88 (sarilumab) – Regeneron Pharmaceuticals Inc. 62
4.4.4 CNTO 136 (sirukumab) – Johnson and Johnson 62
4.4.5 AIN457 (secukinumab) – Novartis 63
4.4.6 ALD-518 – Alder Biopharmaceuticals Inc. 63
4.4.7 BT-061 (tregalizumab) – Biotest A.G. 63
4.4.8 MLTA3698A (pateclizumab) – Genentech Inc. 64
4.4.9 MOR 103 – MorphoSys A.G. 64
4.5 Heat Map of Safety and Efficacy for Pipeline and Marketed Products 65
4.6 Conclusion 66
5 Market Forecast to 2018 68
5.1 Geographical Markets 68
5.1.1 Global Market 69
5.1.2 US 71
5.1.3 UK 73
5.1.4 France 75
5.1.5 Germany 77
5.1.6 Italy 79
5.1.7 Spain 81
5.1.8 Japan 83
5.2 Drivers and Barriers for the mAbs market in Rheumatoid Arthritis 85
5.2.1 Drivers 85
5.2.2 Barriers 87
6 Deals and Strategic Consolidations 90
6.1 Mergers and Acquisition Deals 91
6.1.1 Amgen Completes Acquisition of Micromet, Inc. 91
6.1.2 Pfizer Inc. Completes Acquisition of Wyeth 92
6.1.3 Bristol-Myers Squibb Completes Acquisition of Medarex Inc. 92
6.1.4 Teva Pharmaceutical Industries Limited Acquires CoGenesys Inc. 92
6.1.5 Biotie Therapies Corp. Terminates Acquisition of Newron Pharmaceuticals S.p.A. 92
6.1.6 Emergent BioSolutions Inc. Completes Acquisition of Trubion Pharmaceuticals Inc. 92
6.1.7 Alexion Pharmaceuticals Inc. completes acquisition of Taligen Therapeutics Inc. 93
6.1.8 Ligand Pharmaceuticals Incorporated Completes Acquisition of Pharmacopeia Inc. 93
6.1.9 Astellas Pharma Inc. Completes Acquisition of Perseid Therapeutics LLC 93
6.1.10 Cypress Bioscience Inc. Completes Acquisition of Proprius Pharmaceuticals Inc. 93
6.1.11 Simcere Pharmaceutical Group Completes Acquisition of Shanghai Celgen Bio-Pharmaceutical Co. Ltd. 93
6.2 Major Co-development Deals 94
6.2.1 Abbott Laboratories Enters Worldwide Agreement with Biotest AG 94
6.2.2 Dynavax Technologies Corporation Expands Worldwide Agreement with GlaxoSmithKline plc 95
6.2.3 Astellas Pharma Inc. Enters into Agreement with Maxygen Inc. 95
6.2.4 Tanabe Research Laboratories Enters Agreement with Anaphore Inc. 95
6.3 Major Licensing Deals 96
6.3.1 Hanwha Chemical Corporation Enter Licensing Agreement with Merck Sharp and Dohme Research Ltd. 99
6.3.2 Alder Biopharmaceuticals Inc. Enter Agreement with Bristol-Myers Squibb Company 99
6.3.3 Immunomedics Inc. Enter Agreement with Nycomed International Management GmbH 99
6.3.4 Sanofi-Aventis Enter Agreement with Kyowa Hakko Kogyo Co. Ltd. 99
6.3.5 EUSA Pharma Inc. Enter Licensing Agreement with GlaxoSmithKline plc 100
7 Appendix 101
7.1 All Pipeline Drugs by Phase 101
7.1.1 Discovery 101
7.1.2 Preclinical 102
7.1.3 IND-Filed and Phase 0 106
7.1.4 Phase I 106
7.1.5 Phase II 108
7.1.6 Phase III 110
7.1.7 Undisclosed 111
7.2 Market Forecasts to 2018 112
7.2.1 Global 112
7.2.2 United States 113
7.2.3 Top Five European Countries (Aggregate) 114
7.2.4 UK 115
7.2.5 France 116
7.2.6 Germany 117
7.2.7 Italy 118
7.2.8 Spain 119
7.2.9 Japan 120
7.3 Market Definitions 121
7.4 Abbreviations 121
7.5 References for Heat Maps (Figure 12 and Figure 23) 123
7.6 Sources 125
7.7 Research Methodology 130
7.7.1 Coverage 130
7.7.2 Secondary Research 130
7.7.3 Primary Research 131
7.7.4 Therapeutic Landscape 131
7.7.5 Geographical Landscape 134
7.7.6 Pipeline Analysis 134
7.8 Expert Panel Validation 134
7.9 Contact Us 134
7.10 Disclaimer 134
【レポート販売概要】
■ タイトル：Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018 – Market Characterized by Large and Diversified Pipeline and Low Threat of Biosimilar Sales Erosion■ 発行日：2013年1月31日
■ 調査会社：GBI Research
■ 商品コード：GBIR403170007
■ 調査対象地域：グローバル
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