世界の全エクソーム配列決定（WES）市場予測：技術、用途...市場調査レポートについてご紹介

TABLE OF CONTENTS

1 INTRODUCTION 22
1.1 OBJECTIVES OF THE STUDY 22
1.2 MARKETS COVERED 23
1.3 STAKEHOLDERS 24
1.4 RESEARCH METHODOLOGY 25
1.4.1 SECONDARY RESEARCH 25
1.4.2 PRIMARY RESEARCH 27
1.4.2.1 Key data points from primary sources 28
1.4.3 MARKET SIZE ESTIMATION METHODOLOGY 29
1.4.4 MARKET FORECAST MODEL 32
1.4.5 MARKET DATA VALIDATION AND DATA TRIANGULATION 33
1.5 ASSUMPTIONS 35
2 EXECUTIVE SUMMARY 36
3 MARKET OVERVIEW 41
3.1 INTRODUCTION 42
3.2 MARKET DYNAMICS 42
3.2.1 DRIVERS 43
3.2.1.1 Low cost and high speed of the WES technology to drive the growth of the market 43
3.2.1.2 Increasing number of new scientific applications to fuel the market growth 44
3.2.1.3 Adoption of WES technology by new consumers to propel the market growth 45
3.2.1.4 Global alliances amongst leading research institutes to trigger drug discovery 45
3.2.1.5 Entry of new players is propelling the growth of the WES market 46

3.2.2 RESTRAINTS 47
3.2.2.1 Need for skilled professionals 47
3.2.2.2 High reliability on grants to restrict growth 47
3.2.2.3 Ethical and legal issues related to whole exome sequencing 47
3.2.3 OPPORTUNITY 48
3.2.3.1 Personalized medicine to fuel the demand for WES technology 48
3.3 MARKET SHARE ANALYSIS 49
3.3.1 WHOLE EXOME SEQUENCING PRODUCTS MARKET, BY KEY PLAYER 49
3.3.2 WHOLE EXOME SEQUENCING SERVICES MARKET,
BY KEY PLAYER 53
4 WHOLE EXOME SEQUENCING MARKET, BY PRODUCTS AND SERVICES 59
4.1 INTRODUCTION 60
4.2 SYSTEMS 64
4.2.1 INTRODUCTION 64
4.2.2 HISEQ SERIES 66
4.2.2.1 HiSeq 2500 and HiSeq 1500 66
4.2.3 MISEQ 66
4.2.4 ION TORRENT PLATFORMS 67
4.2.4.1 Ion PGM and Ion Proton 67
4.3 KITS 68
4.3.1 INTRODUCTION 68
4.3.2 DNA FRAGMENTATION, END REPAIR, A-TAILING, AND SIZE SELECTION KITS 71
4.3.3 LIBRARY PREPARATION KITS 73
4.3.4 TARGET ENRICHMENT KITS 75
4.4 SERVICES 77
4.4.1 INTRODUCTION 77
4.4.2 SEQUENCING SERVICES MARKET 78
4.4.3 DATA ANALYSIS (BIOINFORMATICS) SERVICES 80
4.4.4 OTHER SERVICES 81
5 GLOBAL WHOLE EXOME SEQUENCING MARKET,
BY TECHNOLOGY 83
5.1 INTRODUCTION 84
5.2 SEQUENCING BY SYNTHESIS (SBS) 86
5.2.1 TECHNOLOGY 86
5.2.2 ADVANTAGES 86
5.2.3 LIMITATIONS 86
5.2.4 APPLICATIONS 87
5.2.5 PLATFORMS 87
5.3 ION SEMICONDUCTOR SEQUENCING 88
5.3.1 TECHNOLOGY 88
5.3.2 ADVANTAGES 88
5.3.3 LIMITATIONS 88
5.3.4 APPLICATIONS 88
5.3.5 PLATFORMS 89
5.4 OTHER TECHNOLOGIES 90
5.4.1 SEQUENCING BY LIGATION (SBL) 90
5.4.1.1 Technology 90
5.4.1.2 Advantages 90
5.4.1.3 Limitations 90
5.4.1.4 Applications 90
5.4.2 PYROSEQUENCING 91
5.4.2.1 Technology 91
5.4.2.2 Advantages 91
5.4.2.3 Applications 91
6 WHOLE EXOME SEQUENCING MARKET, BY APPLICATION 93
6.1 INTRODUCTION 94
6.2 DIAGNOSTICS 96
6.2.1 CANCER DIAGNOSTICS 99
6.2.2 MONOGENIC (MENDELIAN) DISORDERS 100
6.2.3 MONOGENIC TYPES OF DIABETES 102
6.2.4 OTHER DIAGNOSTIC APPLICATIONS 103
6.2.4.1 Common diseases and complex disorders 103
6.2.4.2 Movement disorders 103
6.2.4.3 HIV 103
6.3 DRUG DISCOVERY AND DEVELOPMENT 105
6.4 PERSONALIZED MEDICINE 107
6.5 AGRICULTURE & ANIMAL RESEARCH 109
6.6 OTHER APPLICATIONS 111
7 GLOBAL WHOLE EXOME SEQUENCING MARKET, BY END USER 112
7.1 INTRODUCTION 113
7.1.1 RESEARCH CENTERS AND ACADEMIC & GOVERNMENT INSTITUTES 115
7.1.2 HOSPITALS AND CLINICS 117
7.1.3 PHARMACEUTICAL & BIOTECHNOLOGY COMPANIES 118
7.1.4 OTHER END USERS 120
8 GLOBAL WHOLE EXOME SEQUENCING MARKET, BY GEOGRAPHY 121
8.1 INTRODUCTION 122
8.2 NORTH AMERICA 124
8.2.1 INCREASING USE OF WHOLE EXOME SEQUENCING FOR DIAGNOSIS OF RARE DISEASES PROPELS THE MARKET GROWTH 124
8.2.2 GOVERNMENT FUNDS FOR EXOME SEQUENCING TO BOOST THE MARKET 125
8.2.3 FAVORABLE INITIATIVES BY THE CANADIAN GOVERNMENT TO TRIGGER THE WES MARKET IN THE COUNTRY 125
8.2.4 CONFERENCES & ANNUAL MEETINGS TO CREATE AWARENESS ABOUT WES TECHNOLOGIES 126
8.3 EUROPE 137
8.3.1 INVESTMENTS IN RARE DISEASE RESEARCH LIKELY TO BOOST THE WES MARKET IN EUROPE 137
8.3.2 BELGIUM TO CONTRIBUTE SUBSTANTIALLY TO MARKET GROWTH IN EUROPE 138
8.3.3 INCREASING FUNDING FOR MOLECULAR DIAGNOSTICS IN EUROPE IS LIKELY TO PROPEL THE GROWTH OF THE WES MARKET 138
8.3.4 CONFERENCES & MEETINGS HOSTED IN EUROPE TO FUEL THE MARKET GROWTH 139
8.4 ASIA 150
8.4.1 ASIAN COUNTRIES ARE INCREASINGLY FOCUSING ON RESEARCH IN WES 150
8.4.2 STRATEGIC EXPANSIONS AND AQUISITIONS BY KEY PLAYERS IN CHINA TO BOOST THE MARKET 151
8.4.3 REGULAR FUNDING FROM INDIAN GOVERNMENT, AN IMPETUS TO THE WES MARKET 151
8.4.4 LARGE NUMBER OF CONFERENCES AND SYMPOSIA IN ASIA TO DRIVE MARKET GROWTH 152
8.5 REST OF THE WORLD (ROW) 161
8.5.1 BIOINFORMATICS AND BIOTECHNOLOGY RESEARCH IN LATIN AMERICA TO PROPEL THE GROWTH OF THE MARKET 162
8.5.2 GENOMIC & PROTEOMIC RESEARCH IN AUSTRALIA TO DRIVE THE GROWTH OF THE MARKET 162
8.5.3 FLOURISHING BIOTECHNOLOGY & PHARMACEUTICAL MARKETS IN BRAZIL TO BOLSTER THE GROWTH OF THE MARKET 163
9 COMPETITIVE LANDSCAPE 171
9.1 INTRODUCTION 171
9.2 AGREEMENTS, PARTNERSHIPS, & COLLABORATIONS 173
9.3 NEW PRODUCT LAUNCHES 176
9.4 EXPANSIONS 180
9.5 ACQUISITIONS 183
9.6 OTHERS 186
10 COMPANY PROFILES 189
10.1 ILLUMINA, INC. 189
10.2 THERMO FISHER SCIENTIFIC, INC. 196
10.3 BEIJING GENOMICS INSTITUTE (BGI) 204
10.4 MACROGEN, INC. 213
10.5 EUROFINS GENOMICS, INC. 217
10.6 AGILENT TECHNOLOGIES, INC. 222
10.7 AMBRY GENETICS 229
10.8 GENEWIZ, INC. 231
10.9 KNOME, INC. 234
10.10 ROCHE NIMBLEGEN, INC. 238
10.11 SENGENICS 243

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