【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 12
1.2 List of Figures 14
2 Introduction 16
2.1 Catalyst 16
2.2 Related Reports 17
2.3 Upcoming Related Reports 17
3 Disease Overview 18
3.1 Etiology and Pathophysiology 19
3.2 Prognosis 21
3.3 Quality of Life 22
3.4 Symptoms 23
3.5 Diagnosis 25
4 Epidemiology 30
4.1 Disease Background 30
4.2 Risk Factors and Comorbidities 31
4.3 Global Trends 32
4.3.1 US 32
4.3.2 5EU 32
4.4 Forecast Methodology 33
4.4.1 Sources Used 36
4.4.2 Sources Not Used 38
4.4.3 Forecast Assumptions and Methods – Prevalent Cases 39
4.4.4 Forecast Assumptions and Methods – Immediate TSS Outcomes 40
4.5 Epidemiological Forecast for Cushing’s Syndrome (2013-2023) 40
4.5.1 Cushing’s Syndrome 40
4.5.2 Cushing’s Disease 46
4.5.3 Ectopic Adrenocorticotropic Hormone Cushing’s Syndrome 51
4.5.4 Adrenal Adenoma Cushing’s Syndrome 57
4.5.5 Adrenal Carcinoma Cushing’s Syndrome 62
4.5.6 Age-Standardized Diagnosed Prevalence Rates 67
4.5.7 Immediate Transsphenoidal Adenomectomy Surgery Outcomes 69
4.6 Discussion 70
4.6.1 Epidemiological Forecast Insight 70
4.6.2 Limitations of the Analysis 71
4.6.3 Strengths of the Analysis 72
5 Current Treatment Options 73
5.1 Overview 73
5.2 Treatment Approach 74
5.3 Product Profiles – Major Brands 78
5.3.1 Signifor (pasireotide) and Signifor LAR (pasireotide) 78
5.3.2 Korlym (mifepristone) 87
5.3.3 Ketoconazole and Ketoconazole HRA (ketoconazole) 96
5.3.4 Metopirone (metyrapone) 103
5.3.5 Lysodren (mitotane) 109
6 Unmet Needs Assessment and Oppportunity Analysis 114
6.1 Overview 114
6.2 Unmet Needs Analysis 115
6.2.1 Unmet Need: Effective Drugs Directed against the Underlying Cause of Cushing’s Disease 115
6.2.2 Unmet Need: Few Drugs – Especially Those for Severe Cushing’s Syndrome – Possess Favorable Safety and Efficacy 116
6.2.3 Unmet Need: Physician Awareness of Cushing’s Syndrome Symptomatology 118
6.2.4 Unmet Need: Accelerated Referral Systems to Specialists in Secondary and Tertiary Care Settings 119
6.2.5 Unmet Need: Uniform Guidelines Unambiguously Defining Treatment and Remission 121
6.3 Opportunity Analysis 121
6.3.1 Opportunity: Development of Improved Adrenocorticotropic Hormone Modulator Drugs 121
6.3.2 Opportunity: Reformulation of the Steroidogenic Inhibitors into Longer-Acting Release Treatments 122
6.3.3 Opportunity: Development of Universally Accepted Tests and Measures for Better Diagnosis and Monitoring of Cushing’s Syndrome Activity and Treatment Response 122
6.3.4 Opportunity: Prospective, Randomized Trials for Off-Label Cushing’s Syndrome Agents 123
6.3.5 Opportunity: Gaining Understanding of the Pathophysiology of Cushing’s Syndrome 124
7 Research and Development Strategies 125
7.1 Overview 125
7.1.1 Inhibitors of Cortisol Synthesis in the Adrenal Glands 125
7.1.2 Licensing Agreements, Partnerships, and Alliances 126
7.1.3 Secondary Indications 127
7.2 Clinical Trial Design 128
7.2.1 Selecting Suitable Comparator Arms 128
7.2.2 Evaluating and Determining Appropriate Clinical Trial Endpoints 129
7.2.3 Accurately Representing the Patient Population in Clinical Trials 131
8 Pipeline Assessment 135
8.1 Overview 135
8.2 Promising Drugs in Clinical Development 135
8.2.1 NormoCort (COR-003) 136
8.2.2 LCI699 141
8.3 Innovative Early-Stage Approaches 146
8.3.1 Somatoprim (DG3173) 147
8.3.2 Anti-Sense Technology and RNA Interference 147
8.3.3 Retinoic Acid 148
8.3.4 Other Early-Stage Approaches and Non-Pharmacotherapies 149
9 Pipeline Valuation Analysis 151
9.1 Clinical Benchmark of Key Pipeline Drugs 151
9.2 Commercial Benchmark of Key Pipeline Drugs 153
9.3 Competitive Assessment 154
9.4 Top-Line Five-Year Forecast 156
9.4.1 US 158
9.4.2 5EU 159
10 Appendix 161
10.1 Bibliography 161
10.2 Abbreviations 178
10.3 Methodology 180
10.4 Forecasting Methodology 180
10.4.1 Diagnosed Cushing’s Syndrome Patients 180
10.4.2 Percent Drug-Treated Patients 181
10.4.3 Drugs Included in Each Therapeutic Class 181
10.4.4 Launch and Patent Expiry Dates 182
10.4.5 General Pricing Assumptions 183
10.4.6 Individual Drug Assumptions 183
10.4.7 Pricing of Pipeline agents 187
10.5 Physicians and Specialists Included in This Study 189
10.6 About the Authors 190
10.6.1 Analyst 190
10.6.2 Therapy Director 190
10.6.3 Epidemiologist 191
10.6.4 Global Head of Healthcare 192
10.7 About GlobalData 193
10.8 Disclaimer 193
【レポート販売概要】
■ タイトル：クッシング症候群治療薬の世界市場機会分析■ 英文：OpportunityAnalyzer: Cushing’s Syndrome - Opportunity Analysis and Forecasts to 2018
■ 発行日：2015年1月9日
■ 調査会社：GlobalData
■ 商品コード：GDHC026POA
■ 調査対象地域：グローバル
- 高フェニルアラニン血（Hyperphenylalaninemia）：グローバル臨床試験レビュー（2014年上半期）Hyperphenylalaninemia Global Clinical Trials Review, H1, 2014 Summary GlobalData's clinical trial report, “Hyperphenylalaninemia Global Clinical Trials Review, H1, 2014" provides data on the Hyperphenylalaninemia clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Hyperphenylalaninemia. It includes an overview of the trial numbers and the …
- シェールガスの世界市場2018-2022About Shale Gas Shale formations are fine-grained sedimentary rocks with low permeability. They might be rich sources of petroleum and natural gas. Natural gas produced from shale formations is called shale gas. Technavio’s analysts forecast the global shale gas market to grow at a CAGR of 5.35% during the period 2018-2022. Covered in this report The report covers the present scenario and the grow …
- 変圧器監視ソリューションの世界市場：配電変圧器監視、電源変圧器監視About Transformer Monitoring Solutions Transformer monitoring solutions monitor and diagnose the health of a transformer. A monitoring solution helps end-users to detect and identify any failure in transformers before it becomes evident, thereby reducing the costs involved in repair. A transformer monitoring solution is an integration of sensors, data management and analysis, and software applicat …
- MES（製造実行システム）のグローバル市場(2014-2020)Manufacturing Execution System has transformed the conventional manufacturing unit into a modern service center. MES focuses more on improving the process capability than production capability. MES has helped manufacturers achieve high productivity at reduced cost in short time, and over a period, manufacturers have improved on overall manufacturing process as well. The improved process capability …
- エチレンオキシド(EO)の世界市場予測Ethylene Oxide 2013 World Market Outlook and Forecast is an absolutely essential resource for anyone looking for detailed information on the mentioned market. Using a wide range of primary and secondary sources, we combined, analyzed and presented all available data about ethylene oxide market in the all-in-one report issued in a logical and easily accessible format. In addition to the analytical …
- ソフトウェアテスト・システムインテグレーションの世界市場About Software Testing System Integration Software testing is one of the important aspects of software development and is a process of analyzing software products to identify the correctness, security, and quality of developed and purchased software. With the number of large projects and involvement of various teams associated in the development process, the complexity of software development and …
- 止血装置の世界市場2017-2021ABSTRACTAbout Tourniquets Device A tourniquet is a compressing device used to control or resist blood flow during accidents or surgical procedures. Pressure is applied circumferentially to the skin and the underlying tissues of a limb; this pressure causes a temporary occlusion. Tourniquets are segmented into two types based on product type –– pneumatic and non-pneumatic tourniquets. Pneumatic tou …
- 熱画像ソリューションの世界市場：熱画像装置、ソフトウェア、サービスThermal Imaging is changing the world with the applications ranging from military to personal handheld cameras and smartphones. The global thermal imaging market has witnessed a significant demand owing to the increasing adoption of related devices across a diverse range of applications. The thermal imaging market is fast gaining traction primarily due to decreasing cost and increasing usage in va …
- 抗菌包装の世界市場：プラスチック、バイオポリマー、板紙、有機酸、バクテリオシン、酵素、エッセンシャルオイル、金属イオン、酸化剤MarketsandMarkets projects that the antimicrobial packaging market size will grow from USD 7.28 Billion in 2015 to USD 10.00 Billion by 2021, at an estimated CAGR of 5.54%. The rising concerns toward food wastage, growing consumer awareness about health-related issues, rising consumption of products with shorter shelf life such as meat products, and increasing demand by various end-user industries …
- 腫瘍治療薬の中国市場：化学療法、標的療法、免疫療法、ホルモン療法The China oncology drugs market was valued at $6,498.2 million in 2018 and is projected to reach $12,688.7 million by 2026, registering a CAGR of 8.7% from 2019 to 2026. Cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer according to the data published by WHO. Being the most populous co …
- トップ10ケアケミカルの世界市場予測（～2021）：カラー化粧品、パーソナルケア成分、活性成分、香料成分、業務用I＆I洗浄剤、界面活性剤、軟化エステル、化粧用顔料、化粧品防腐剤、エトキシレートCare chemicals are used for personal, workplace, and industrial hygiene. There care chemicals used in industries, homes, and toiletries across the globe. The various types of care chemicals are used in color and other cosmetics. Increasing urbanization, rising participation of working women, and increasing concern towards physical appearance and beauty are some of the key drivers in the global car …
- 世界のタブレット用コンボチップ市場動向：Global Combo-chip for Tablet Market 2014-2018TechNavio's analysts forecast the Global Combo-chip for Tablet market to grow at a CAGR of 41.3 percent over the period 2014-2018. One of the key factors contributing to this market growth is the increasing sales of tablets worldwide. The Global Combo-chip market for Tablets has also been witnessing technological convergence. However, the high cost of integration could pose a challenge to the grow …
- 放射線治療の世界市場予測（～2023年）“The radiotherapy market is projected to grow at a CAGR of 4.1% during the forecast period”The global radiotherapy market is projected to reach USD 6.8 billion by 2023 from USD 5.6 billion in 2018, at a CAGR of 4.1%. Growth in this market is largely driven by factors such as the growing global prevalence of cancer, increasing adoption of radiotherapy in clinical trials, and the increasing number o …
- ESD（静電気放電）パッケージングの世界市場2017-2021ABSTRACTAbout ESD Packaging ESD packaging is used for devices or products that can be damaged by electrostatic discharge (ESD). ESD is the sudden flow of electricity between two electrically charged objects. This flow of electricity may result in the damage of devices. ESD packaging is commonly used for packaging printed circuit boards (PCBs) and semiconductors. PCBs are mostly used in industries …
- 初代細胞の世界市場予測（～2023年）：造血、血液、皮膚、消化器官、肝細胞、腎細胞、骨格・筋肉The global primary cells market is expected to reach USD 1,107.3 million by 2023 from USD 736.4 million in 2018, at a CAGR of 8.5%. Growth in the primary cells market is mainly driven by factors such as increasing cancer research; the advantages of primary human cells over cell lines; the increasing demand for monoclonal antibodies; rapid growth in the biotechnology and biopharmaceutical industrie …
