【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 7
1.2 List of Figures 7
2 Introduction 9
2.1 Disease Introduction 9
2.2 Route of HIV Transmission 10
2.3 Etiology 10
2.4 Classification of HIV-1 Subtypes 11
2.5 Pathophysiology 11
2.5.1 HIV-1 Replication Cycle 12
2.5.2 Mechanism of CD4 T-Cell Death 13
2.5.3 Latent Infection and Viral Persistence 14
2.6 Symptoms 14
2.7 Diagnosis 15
2.7.1 HIV Antibody Assay 15
2.7.2 Rapid HIV Antibody Test 16
2.7.3 Western Blot 16
2.7.4 HIV p24 Antigen Test 16
2.7.5 Antigen-Antibody Immunoassay 16
2.7.6 Polymerase Chain Reaction Test 16
2.7.7 HIV Home-Testing Kit 17
2.8 Disease Staging 17
2.8.1 WHO Clinical Staging 17
2.8.2 Centers for Disease Control and Prevention Classification System 19
2.8.3 Immunological Classification 19
2.9 Co-morbidities and Complications 20
2.10 Epidemiology 21
2.11 Treatment Options 22
2.11.1 Nucleoside/Nucleotide Reverse Transcriptase Inhibitor 23
2.11.2 Non-Nucleoside Reverse Transcriptase Inhibitor 23
2.11.3 Entry Inhibitor 23
2.11.4 Integrase Inhibitor 23
2.11.5 HIV-1 Protease Inhibitor 24
2.11.6 Pharmacokinetic Enhancer 24
2.12 Treatment Algorithm 24
3 Marketed Products 29
3.1 Therapeutic Landscape 31
3.1.1 Multi-class Combinations 31
3.1.2 Nucleotide Reverse Transcriptase Inhibitors 35
3.1.3 Non-Nucleoside Reverse Transcriptase Inhibitor 44
3.1.4 HIV Protease Inhibitor 48
3.1.5 Integrase Inhibitor 55
3.1.6 Entry Inhibitor 57
3.2 Comparative Efficacy and Safety 60
3.2.1 Multi-class Combination 62
3.2.2 Nucleotide Reverse Transcriptase Inhibitor 62
3.2.3 Non-Nucleotide Reverse Transcriptase Inhibitor 63
3.2.4 HIV Protease Inhibitor 63
3.2.5 Integrase Inhibitor 64
3.2.6 Entry Inhibitor 64
3.3 Unmet Need 65
4 Pipeline for HIV 67
4.1 Overall Pipeline 67
4.2 Mechanism of Action in HIV Pipeline 70
4.3 Clinical Trials 72
4.3.1 Failure Rate of Developmental Pipeline 72
4.3.2 Clinical Trial Sizes 76
4.3.3 Clinical Trial Duration 80
4.3.4 Summary of Clinical Trial and Risk Analysis 84
4.4 Promising Candidates in Pipeline 85
4.4.1 572-Trii (dolutegravir + abacavir sulfate + lamivudine) – Shionogi-ViiV Healthcare 85
4.4.2 Atazanavir sulfate + cobicistat – Bristol-Myers Squibb, Gilead 86
4.4.3 Elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide – Gilead 88
4.4.4 Apricitabine – Avexa 90
4.4.5 Remune (IR-103) – Immune Response BioPharma 91
4.4.6 Censavudine – Bristol-Myers Squibb 93
4.4.7 Elvucitabine – Achillion 94
4.4.8 Cenicriviroc – Tobira Therapeutics 95
4.5 Heat Map and Competitor Matrix for HIV Pipeline Products 97
5 Market Forecast to 2019 103
5.1 Geographical Markets 103
5.1.1 Global Market 106
5.1.2 North America 107
5.1.3 Top Five Countries in Europe 112
5.1.4 Japan 117
5.2 Drivers and Barriers 119
5.2.1 Drivers 119
5.2.2 Barriers 120
6 Deals and Strategic Consolidations 122
6.1 Major Co-development Deals 122
6.1.1 DFH Pharma Enters Agreement with Hetero Drugs 124
6.1.2 GlaxoSmithKline Enters Agreement with Concert Pharmaceuticals 125
6.1.3 GenVec Enters Agreement with SAIC-Frederick 125
6.2 Major Licensing Deals 125
6.2.1 Merck Enters Agreement with Chimerix 128
6.2.2 Bristol-Myers Squibb Enters Agreement with Gilead 128
6.2.3 Japan Tobacco Enters Agreement with Gilead 129
6.2.4 Gilead Enters Agreement with Tibotec 129
6.2.5 Benitec Enters Agreement with Calimmune 129
6.2.6 Bristol-Myers Squibb Enters Agreement with Oncolys BioPharma 129
7 Appendix 130
7.1 All Pipeline Products, by Phase 130
7.1.1 Discovery 130
7.1.2 Preclinical 137
7.1.3 Phase I 142
7.1.4 Phase II 145
7.1.5 Phase III and Pre-registration 148
7.2 Tabular Forecast Data 149
7.2.1 Global 149
7.2.2 US 149
7.2.3 Canada 150
7.2.4 UK 150
7.2.5 France 150
7.2.6 Germany 151
7.2.7 Italy 151
7.2.8 Spain 152
7.2.9 Japan 152
7.3 Sources 153
7.4 Market Definition 164
7.5 Abbreviations 164
7.6 Research Methodology 167
7.6.1 Coverage 167
7.6.2 Secondary Research 167
7.7 Therapeutic Landscape 167
7.8 Epidemiology-Based Forecasting 168
7.9 Market Size by Geography 169
7.10 Geographical Landscape 169
7.11 Pipeline Analysis 170
7.12 Competitive Landscape 170
7.12.1 Expert Panel Validation 170
7.13 Contact Us 170
7.14 Disclaimer 170
【レポート販売概要】
■ タイトル：主要先進国におけるHIV治療動向（～2019）■ 英文：HIV Therapeutics in Major Developed Markets to 2019 - Limited Pipeline Efficacy Improvement, Patent Expirations and Stringent Healthcare Spending to Suppress Market Growth
■ 発行日：2014年4月14日
■ 調査会社：GBI Research
■ 商品コード：GBIHC328MR
■ 調査対象地域：グローバル
- 末梢血管インターベンション機器の世界市場分析・予測MediPoint: Peripheral Vascular Interventions - Global Analysis and Market Forecasts Summary The peripheral vascular interventions market is a dynamic, billion-dollar market with solid growth potential through 2022. The rising prevalence of peripheral artery disease (PAD) combined with the increasing endovascular procedure rate will ensure that the market will continue to expand in the coming years …
- ホームエネルギー管理システム（HEMS）の世界市場2017-2021About Home Energy Management SystemsHEMS are devices that are installed in residential buildings to enable the provision of feedback on electricity consumption patterns and power consumption data for individual appliances. These systems perform pre-programmed functions, such as maintaining the temperature of houses. In addition, HEMS not only provide demand-response prompts from utility loads but …
- 変圧器の世界市場予測Report Description Introduction Transformer is a diverse subject area, which includes both, small and very large systems. Transformer is broadly segmented into distribution transformer, power transformer, and others (instrument transformer). Transformer systems have been dominating the renewable energy market and conventional market in recent years because of the ability to transmit and distribute …
- El Paso Electric Company：発電所及び企業SWTO分析2015El Paso Electric Company - Power Plants and SWOT Analysis, 2015 Update Summary The report contains a detailed description of the power generation company’s business operations, history, corporate strategy, and business structure. This report contains a detailed SWOT analysis, information on key employees (executives), and major products and services. Scope - Major Power Plants (assets) - summarize …
- 電動式コントロールバルブ（調節弁）の世界市場About Motorized Control ValvesMotorized control valves are valves that are equipped with actuators or motors. These are used as on/off valves in many of the end-user industries for flow control in various industrial processes. The motor or an actuator designated for valves is connected to a control panel that helps in remote controlling of valves. Technavio’s analysts forecast the global motorized …
- フォン・ウィルブランド病治療の世界市場2019-2023138 pages, November 2018 About this market The increasing awareness about VWD is likely to boost growth in the market. VWD will be present in the affected individual since the time of birth; however, the symptoms do not appear from childhood. Patients’ perceptions of symptoms such as frequent nosebleeds, staining and extreme bleeding during and after invasive events such as dental extractions and …
- 世界のキャンプ用寝袋市場2015The Global Camping Sleeping Bags Industry Report 2015 is a professional and in-depth study on the current state of the Camping Sleeping Bags industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Camping Sleeping Bags market analysis is provided for the international markets including development trends, …
- 防爆電気モーター・アクチュエーターの世界市場2019-2023About this market Growing need for customized and compact explosion-proof motors to drive growth in the market. Vendors are constantly trying to differentiate their products. The stringent regulations norms regarding the equipment safety in harsh environments have prompted the vendors to constantly improve their explosion-proof motors products. The growing variations of applications, varying clima …
- 冷蔵・冷凍倉庫の世界市場予測（～2022年）：噴射冷却、蒸気圧縮、PLC、気化冷却The refrigerated warehousing market is projected to grow at a CAGR of 10.2% from 2017, to reach a value of USD 29.17 Billion by 2022. The global demand for refrigerated warehousing is increasing significantly due to the growing demand for frozen food products such as fish, meat, and seafood, leading to a rise in the requirement for refrigerated storage for these perishable foods. Growing health-co …
- Kableの市場機会予測（～2018）:クラウドサービスSummary Kable's Market Opportunity Forecast outlines the primary findings from our ongoing research into the dynamics in the Cloud Services market. Key Findings This product provides revenue opportunity forecasts in the Cloud Services market from 2014 to 2018, spanning three services segments, 37 geographical markets, 6 regions, 14 verticals and two size bands. Synopsis The extended scope of this …
- ホームアクセサリーの日本市場：PC、カメラ、ビデオカメラ、ビデオゲーム、レコーダーHome accessories are electronic (analog or digital) equipment intended for everyday use, in homes. Home accessories can be categorized into small appliance or brown goods consumer electronics. These are generally equipped with special connections such as electrical or an inbuilt battery that helps in mobility of the appliances around the house. Small appliances are semi-portable or portable machin …
- 世界の自動体外式除細動器市場The automated external defibrillatormarket is segmented based on product type into two categories - semi-automated and fully automated defibrillators. Based on end-users,the AED market is classified into five categories, namely, hospitals, pre-hospital, public access, alternate care, and home; the market is forecast till 2017.Automated external defibrillators play an important role in saving the l …
- 前立腺がんの疫学的予測（～2023）EpiCast Report: Prostate Cancer - Epidemiology Forecast to 2023 Summary Prostate cancer is a malignant tumor that forms in the tissues of the prostate, a gland in the male reproductive system found below the bladder and in front of the rectum. Although prostate cancer cases have been reported in all age groups, the majority of cases occur in men over the age of 65 years. Prostate cancer is the sec …
- 初代細胞の世界市場予測（～2023年）：造血、血液、皮膚、消化器官、肝細胞、腎細胞、骨格・筋肉The global primary cells market is expected to reach USD 1,107.3 million by 2023 from USD 736.4 million in 2018, at a CAGR of 8.5%. Growth in the primary cells market is mainly driven by factors such as increasing cancer research; the advantages of primary human cells over cell lines; the increasing demand for monoclonal antibodies; rapid growth in the biotechnology and biopharmaceutical industrie …
- 世界の自動車サイドエアバッグ市場2015The Global Automotive Side Airbags Industry 2015 Market Research Report is a professional and in-depth study on the current state of the Automotive Side Airbags industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Automotive Side Airbags market analysis is provided for the international markets includin …
