【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 9
1.1 List of Tables 13
1.2 List of Figures 15
2 Introduction 16
2.1 Catalyst 16
2.2 Related Reports 17
2.3 Upcoming Related Reports 17
3 Disease Overview 18
3.1 Etiology and Pathophysiology 19
3.1.1 Etiology 19
3.1.2 Pathophysiology 20
3.2 Prognosis 21
3.3 Clinical Staging 21
3.4 Symptoms 25
4 Epidemiology 26
4.1 Disease Overview 26
4.2 Risk Factors and Comorbidities 26
4.2.1 The risk of developing pancreatic cancer increases with age 27
4.2.2 Tobacco smokers have a two-fold increased risk of pancreatic cancer 27
4.2.3 Diabetes and obesity increase the risk of developing pancreatic cancer 27
4.2.4 At least 10% of pancreatic cancer cases result from a hereditary predisposition 28
4.3 Global Trends 29
4.3.1 United States 29
4.3.2 France 30
4.3.3 Germany 31
4.3.4 Italy 32
4.3.5 Spain 33
4.3.6 United Kingdom 34
4.4 Forecast Methodology 35
4.4.1 Sources Used 36
4.4.2 Forecast Assumptions and Methods 38
4.4.3 Sources Not Used 40
4.5 Epidemiology Forecast 40
4.5.1 Incident Cases of Pancreatic Cancer 40
4.5.2 Total Five-Year Prevalent Cases of Pancreatic Cancer 47
4.6 Discussion 49
4.6.1 Conclusions on Epidemiological Trends 49
4.6.2 Limitations of the Analysis 50
4.6.3 Strengths of the Analysis 50
5 Current Treatment Options 52
5.1 Overview 52
5.2 Product Profiles — Major Brands 55
5.2.1 Abraxane 55
5.2.2 Gemcitabine 59
5.2.3 Tarceva 63
6 Unmet Needs Assessment and Opportunity Analysis 67
6.1 Overview 67
6.2 Unmet Needs Analysis 69
6.2.1 Therapies That Improve Overall Survival Outcomes for Advanced Patients 69
6.2.2 Effective Adjuvant Treatments That Prevent Recurrence of Disease 70
6.2.3 Earlier Diagnosis of Disease 71
6.2.4 Discovery of Predictive Biomarkers and Understanding of Underlying Causes of Disease 71
6.2.5 Treatment Options for Gemcitabine-Refractory Metastatic Patients 72
6.3 Opportunity Analysis 73
6.3.1 Predictive Biomarker-Driven Targeted Therapies in Combination with Chemotherapy Regimens 73
6.3.2 Treatment for Patients with Early-Stage, Localized Pancreatic Cancer 74
6.3.3 Target Patients with Poor Performance Status 75
6.3.4 Effective Drug Delivery 76
6.3.5 Establish New Chemotherapy to be Standard-of-Care Cytotoxic 77
6.3.6 Development of New Standard of Care for Gemcitabine-Refractory Advanced Patients 78
7 Research and Development Strategies 79
7.1 Overview 79
7.1.1 Reformulation strategies 79
7.1.2 Small/Medium-Sized Pharmaceutical Companies Driving R&D 80
7.1.3 Large Pharmaceutical Companies Betting On Targeted Drug Approaches 81
7.2 Clinical Trial Design 82
7.2.1 Overview 82
7.2.2 Overall Survival is the Primary Endpoint of Choice in Both Adjuvant and Metastatic Trials 85
7.2.3 The Majority of Metastatic Trials Are in Second-Line and Later Patients 86
7.2.4 Gemcitabine: Backbone Therapy and Standard Active Comparator for First-Line Metastatic Trials 87
8 Pipeline Assessment 89
8.1 Overview 89
8.2 Promising Drugs in Clinical Development 91
8.2.1 Algenpantucel-L 92
8.2.2 TH-302 96
8.2.3 Lipoplatin 101
8.2.4 MM-398 104
8.2.5 Glufosfamide 109
8.2.6 90Y-Clivatuzumab Tetraxetan 112
8.3 Innovative Early-Stage Approaches 116
8.3.1 Vaccine and Immunotherapy Combination 118
8.3.2 JAK Inhibition 119
8.3.3 Dual MEK/PI3K inhibition 120
8.3.4 Cancer Stem Cell Targeting 123
8.3.5 Poly (ADP-Ribose) Polymerase Inhibitors 125
8.3.6 Drug Delivery Mechanisms 126
8.3.7 Hedgehog Pathway 127
9 Pipeline Valuation Analysis 130
9.1 Clinical Benchmarking of Key Pipeline Drugs 131
9.2 Commercial Benchmarking of Key Pipeline Drugs 134
9.3 Competitive Assessment 137
9.4 Top-Line Five-Year Forecast 138
9.5 US 141
9.6 Europe 143
10 Appendix 145
10.1 Bibliography 145
10.2 Abbreviations 163
10.3 Methodology 167
10.4 Forecasting Methodology 167
10.4.1 Diagnosed Pancreatic Cancer Patients 167
10.4.2 Percent Drug-Treated 168
10.4.3 Drugs Included in Each Therapeutic Class 168
10.4.4 Launch and Patent Expiry Dates 168
10.4.5 General Pricing Assumptions 169
10.4.6 Individual Drug Assumptions 170
10.4.7 Generic Erosion 174
10.5 Physicians and Specialists Included in this Study 175
10.6 About the Authors 176
10.6.1 Authors 176
10.6.2 Epidemiologists 177
10.6.3 Global Head of Healthcare 177
10.7 About GlobalData 178
10.8 Disclaimer 178
【レポート販売概要】
■ タイトル:膵癌治療市場機会分析及び予測(~2017)■ 英文:OpportunityAnalyzer: Pancreatic Cancer - Opportunity Analysis and Forecasts to 2017
■ 発行日:2014年3月27日
■ 調査会社:GlobalData
■ 商品コード:GDHC016POA
■ 調査対象地域:グローバル
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