【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 11
1.1 List of Tables 17
1.2 List of Figures 23
2 Introduction 25
2.1 Catalyst 25
2.2 Related Reports 26
2.3 Upcoming Related Reports 27
3 Disease Overview 28
3.1 Etiology 28
3.1.1 MRSA Strains 31
3.1.2 VISA Strains 33
3.1.3 VRSA Strains 33
3.2 Pathophysiology 34
3.2.1 Infection Sites 34
3.2.2 Expression of Virulence Factors 36
3.2.3 Mechanisms of Antibiotic Resistance 38
3.2.4 Biofilm Formation 42
3.3 Symptoms 43
3.4 Prognosis 44
3.4.1 Skin and Soft Tissue Infections 45
3.4.2 Pneumonia 45
3.4.3 Bacteremia 45
3.4.4 Chronic MRSA Infection 46
4 Epidemiology 47
4.1 Disease Background 47
4.2 Risk Factors and Comorbidities 48
4.3 Global Trends 50
4.3.1 US 50
4.3.2 5EU 51
4.3.3 Japan 51
4.4 Forecast Methodology 52
4.4.1 Sources Used 54
4.4.2 Sources Not Used 67
4.4.3 Forecast Assumptions and Methods 68
4.5 Epidemiological Forecast for MRSA (2014-2024) 74
4.5.1 Hospitalized Incident Cases of MRSA 74
4.5.2 Sex-Specific Hospitalized Incident Cases of MRSA 76
4.5.3 Age-Specific Hospitalized Incident Cases of MRSA 78
4.5.4 Age-Standardized Hospitalized Incidence Rate of MRSA 80
4.5.5 Proportion of Hospitalized Incident MRSA Cases by Infection Site 82
4.5.6 Proportion of Hospitalized Incident MRSA Cases by Case Definition 83
4.6 Discussion 84
4.6.1 Epidemiological Forecast Insight 84
4.6.2 Limitations of the Analysis 85
4.6.3 Strengths of the Analysis 86
5 Disease Management 87
5.1 Diagnosis and Treatment Overview 87
5.1.1 Diagnosis 87
5.1.2 Treatment Guidelines 88
5.1.3 Clinical Practice 89
5.2 US 91
5.3 5EU 95
5.4 Japan 98
6 Competitive Assessment 102
6.1 Overview 102
6.2 Product Profiles – Glycopeptides and Lipoglycopeptides 107
6.2.1 Vancomycin 107
6.2.2 Dalvance (dalbavancin) 115
6.2.3 Orbactiv (oritavancin) 124
6.2.4 Vibativ (telavancin) 132
6.2.5 Targocid (teicoplanin) 142
6.3 Product Profiles – Lipopeptides 148
6.3.1 Cubicin (daptomycin) 148
6.4 Product Profiles – Oxazolidinones 157
6.4.1 Zyvox (linezolid) 157
6.4.2 Sivextro (tedizolid phosphate) 169
6.5 Product Profiles – Cephalosporins 178
6.5.1 Teflaro (ceftaroline fosamil) 178
6.5.2 Zevtera (ceftobiprole medocaril) 188
6.6 Product Profiles – Glycylcyclines 197
6.6.1 Tygacil (tigecycline) 197
6.7 Other Antimicrobial Agents 204
7 Unmet Need and Opportunity Analysis 206
7.1 Overview 206
7.2 Drugs with Demonstrated Efficacy in Difficult-to-Treat Patient Populations 209
7.2.1 Unmet Need 209
7.2.2 Gap Analysis 211
7.2.3 Opportunity 212
7.3 Expand Breadth of Clinical Data Outside of Skin Infections 213
7.3.1 Unmet Need 213
7.3.2 Gap Analysis 214
7.3.3 Opportunity 215
7.4 Physician Education 215
7.4.1 Unmet Need 215
7.4.2 Gap Analysis 216
7.4.3 Opportunity 217
7.5 Antibiotics with More Convenient Formulations and Dosing Schedules 218
7.5.1 Unmet Need 218
7.5.2 Gap Analysis 220
7.5.3 Opportunity 221
7.6 Innovative Approaches to Clinical Trial Design 222
7.6.1 Unmet Need 222
7.6.2 Gap Analysis 223
7.6.3 Opportunity 224
7.7 Drugs with Novel Mechanisms of Action 227
7.7.1 Unmet Need 227
7.7.2 Gap Analysis 228
7.7.3 Opportunity 228
7.8 More Affordable Therapies 229
7.8.1 Unmet Need 229
7.8.2 Gap Analysis 230
7.8.3 Opportunity 230
8 Pipeline Assessment 233
8.1 Overview 233
8.2 Promising Drugs in Late-Stage Clinical Development 233
8.2.1 Delafloxacin (RX-3341) 236
8.2.2 Solithromycin (CEM-101) 243
8.2.3 Omadacycline (PTK-0796) 250
8.2.4 KRP-AM1977X 257
8.2.5 Taksta (fusidic acid, oral tablets) 263
8.2.6 Lefamulin (BC-3781) 268
8.2.7 Debio1450 (Debio1452 prodrug) 276
8.2.8 Brilacidin 282
8.3 Other Promising Products in Clinical Development 289
9 Current and Future Players 291
9.1 Overview 291
9.2 Trends in Corporate Strategy 294
9.3 Company Profiles – Current Players 296
9.3.1 Pfizer 296
9.3.2 Merck 298
9.3.3 Allergan 299
9.3.4 The Medicines Company 301
9.3.5 Theravance Biopharma 303
9.3.6 Basilea Pharmaceutica 305
9.3.7 Sanofi 306
9.4 Additional Companies with Promising Pipeline Products 307
9.4.1 Melinta Therapeutics 307
9.4.2 Cempra Pharmaceuticals 308
9.4.3 Paratek Pharmaceuticals 309
9.4.4 Kyorin Pharmaceutical 310
9.4.5 Nabriva Therapeutics 310
9.4.6 Debiopharm International 311
9.4.7 Cellceutix Corporation 311
10 Market Outlook 313
10.1 Global Markets 313
10.1.1 Forecast 313
10.1.2 Drivers and Barriers – Global Issues 321
10.2 US 322
10.2.1 Forecast 322
10.2.2 Key Events 327
10.2.3 Drivers and Barriers 328
10.3 5EU 329
10.3.1 Forecast 329
10.3.2 Key Events 334
10.3.3 Drivers and Barriers 335
10.4 Japan 336
10.4.1 Forecast 336
10.4.2 Key Events 341
10.4.3 Drivers and Barriers 342
11 Appendix 343
11.1 Bibliography 343
11.2 Abbreviations 394
11.3 Methodology 400
11.4 Forecasting Methodology 400
11.4.1 Hospitalized MRSA Patients 400
11.4.2 Percentage of Drug-Treated MRSA Patients 400
11.4.3 Drugs Included in Each Therapeutic Class 401
11.4.4 Launch, Label Expansion, and Patent Expiry Dates 402
11.4.5 General Pricing Assumptions 404
11.4.6 Individual Drug Assumptions 406
11.4.7 Generic Erosion 418
11.4.8 Pricing of Pipeline Agents 418
11.5 Primary Research – KOLs Interviewed for This Report 420
11.6 Primary Research – Prescriber Survey 422
11.7 About the Authors 423
11.7.1 Author and Therapy Area Director 423
11.7.2 Author 423
11.7.3 Epidemiologist 424
11.7.4 Global Director of Therapy Analysis and Epidemiology 424
11.7.5 Global Head of Healthcare 425
11.8 About GlobalData 426
11.9 Disclaimer 426
【レポート販売概要】
■ タイトル:メチシリン耐性黄色ブドウ球菌(MRSA)感染症治療薬の世界市場予測・分析■ 英文:PharmaPoint: Methicillin-Resistant Staphylococcus Aureus (MRSA) - Global Drug Forecast and Market Analysis to 2024
■ 発行日:2015年12月
■ 調査会社:GlobalData
■ 商品コード:GDHC108PIDR
■ 調査対象地域:グローバル
- Babcock & Wilcox Power Generation Group Acquires MEGTEC Systems:M&Aディール分析Babcock & Wilcox Power Generation Group Acquires MEGTEC Systems - Deal Analysis from GlobalData Summary On June 23, 2014, Babcock & Wilcox Power Generation Group (B&W PGG), an equipment manufacturing company, acquired MEGTEC Systems (MEGTEC), an environmental solutions provider, for a purchase consideration of $155m. Following the acquisition, MEGTEC will operate as B&W MEGTEC, a wholly owned subs …
- 世界のテレフタル酸ジメチル(DMT)市場2015The Global Dimethyl Terephthalate (DMT) Industry 2015 Market Research Report is a professional and in-depth study on the current state of the Dimethyl Terephthalate (DMT) industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Dimethyl Terephthalate (DMT) market analysis is provided for the international m …
- EVコネクターの世界市場予測(~2025年)“Increasing EV sales with demand for EV charging points has driven the demand for EV connectors globally” The global EV connectors market is estimated to grow from USD 30 million in 2018 at a CAGR of 18.44% to reach USD 98 million by 2025. Favorable government policies and support in terms of subsidies and grants, tax rebates for EVs, and EV charging points would drive the growth of EV charging st …
- 世界の潜水艦市場(2014-2024):地域別分析Synopsis This report offers detailed analysis of the global Submarine market over the next ten years, and provides extensive market size forecasts by country and sub sector. It covers the key technological and market trends in the Submarine market. Summary "The Global Submarine Market 2014-2024 - Country Analysis: Market Profile" provides details of the key markets in each region, offering an anal …
- 歯科用X線装置の世界市場分析:製品別(口腔内 – 咬合、顎周囲、咬合; 外用 – パノラマ、コーンビームコンピュータ断層撮影)、用途別(医療、化粧品、法医学)、セグメント予測、2013 – 2024The global dental X-ray market size is expected to reach USD 2.4 billion by 2024, according to a new report by Grand View Research, Inc. The dental X-ray market is anticipated to witness lucrative growth during the period 2016 - 2024. This growth is attributed to a majority of factors concerning the prevalence of oral diseases worldwide. The key factors contributing to the growth of this vertical …
- 中東のクラウドインフラサービス市場予測(~2021)The Middle East cloud infrastructure services market is expected to grow from USD 2.31 Billion in 2016 to USD 7.46 Billion by 2021, at a Compound Annual Growth Rate (CAGR) of 26.4% during the forecast period. The major growth drivers of the market include easy access to disaster recovery, faster deployment of infrastructure services & scalability features, enhanced efficiency & business productivi …
- Coal-bed Methane Power Generation Gaining Momentum GloballyCoal-bed Methane Power Generation Gaining Momentum Globally Summary A number of countries around the world are considering adopting Coal-Bed Methane (CBM) as an alternative resource for power generation. The issue of climate change and burgeoning power demand are driving nations to include CBM in their power mix. Countries that have large CBM reserves and are active in its production include Russi …
- インドの自動車部品市場2016-2020About the Auto Component Market in India The Indian auto component industry offers a distinct competitive advantage in terms of cost and quality and this has helped its transformation from a local supplier (to the indigenous auto component industry) to a global supplier of auto parts that caters to big brands in the global automobile industry. A prime example of the confidence that global OEMs hav …
- 世界の企業コンテンツ管理市場動向(2012-2016)TechNavio's analysts forecast the Global Enterprise Content Management market to grow at a CAGR of 12.4 percent over the period 2012-2016. One of the key factors contributing to this market growth is the need for regulatory compliance. The Global Enterprise Content Management market has also been witnessing an increased adoption of ECM in small and medium-sized enterprises (SMEs). However, existen …
- ベビー歩行器の世界市場2016-2020About Baby Walkers Market The global baby walker market is quite prominent in many parts of the world, and is driven by several factors. Growth through organized retail, which is occurring across the globe, is one of the major factors that will likely have a positive impact on the growth of the market over the next five years. The share of organized retail is increasing with changing government po …
- Idemitsu Kosan Co., Ltd.:石油・ガスの開発・生産動向及びコスト分析- 2012Idemitsu Kosan Co., Ltd. Oil & Gas Exploration and Production Operations and Cost Analysis - 2012 Summary Idemitsu Kosan Co., Ltd. Oil & Gas Exploration and Production Operations and Cost Analysis is the latest report from GlobalData, the industry analysis specialists, that offers comprehensive information on the operational and financial performance of the company. The report is an essential sour …
- 原子層堆積(ALD)法の世界市場:タイプ別(フィルム、プリカーサ、材料、その他)、製品タイプ別(酸化アルミニウムALD、触媒ALD、金属ALD、プラズマ使用ALD、その他)、用途別、最終用途別(半導体・電子、化学 、エネルギー、その他)、地域別予測Global Atomic Layer Deposition (ALD) Market to reach USD 3.1 billion by 2025. Global Atomic Layer Deposition (ALD) Market valued approximately USD 1.1 billion in 2016 is anticipated to grow with a healthy growth rate of more than 12.04% over the forecast period 2017-2025. Increasing need for miniaturized components and Nano-technology, advancement in electronic sectors, increasing concern for glob …
- 無機酸市場:タイThis report is a comprehensive research of inorganic acid industry in Thailand. The first two chapters of the report feature the country profile by giving general information on Thailand and by thoroughly studying its economic state, (including key macroeconomic indicators and their development trends). The third chapter covers common business procedures in the country: from starting a project to …
- アプリケーション・コントロールの世界市場:構成要素、アクセスポイント、企業規模、産業別、地域別分析MarketsandMarkets forecasts the application control market size to grow from USD 1.25 Billion in 2015 to USD 1.90 Billion by 2020, at a Compound Annual Growth Rate (CAGR) of 8.7% from 2015 to 2020. The major factors driving the growth of the market are the need to protect data against internal and external threats and the limitations of traditional security solutions to secure applications and dat …
- 整形外科用インプラントの世界市場分析:用途別(脊椎固定、長骨、足・足首、頭蓋顎顔面、関節置換、歯)、セグメント予測The global orthopedic implants market is expected to reach USD 6.2 billion by 2024, according to a new report by Grand View Research, Inc. Major drivers, such as the surging geriatric population count and the increasing number of sports injuries are fueling the demand for the orthopedic prostheses globally. The soaring number of road accidents and sports injuries is continually engendering the mul …