【レポートの概要(一部)】
1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 15
1.2 List of Figures 21
2 Introduction 24
2.1 Catalyst 24
2.2 Related Reports 25
2.3 Upcoming Related Reports 25
3 Disease Overview 26
3.1 Etiology and Pathophysiology 26
3.1.1 Etiology 27
3.1.2 Pathophysiology 29
3.2 Disease Staging Systems 38
3.3 Symptoms 41
3.4 Prognosis 43
3.5 Quality of Life 43
4 Epidemiology 45
4.1 Disease Background 45
4.2 Risk Factors and Comorbidities 46
4.2.1 A family history of Alzheimer’s increases the risk of developing the disease by 7.5 times 47
4.2.2 The APOE ε4 allele triples the risk for AD 48
4.2.3 Cardiovascular risk factors in midlife significantly increase the risk of developing AD in later life 48
4.2.4 The incidence and prevalence of AD double every five years after age 65 years 49
4.2.5 Diabetes doubles the risk of AD in men, but only marginally affects the risk in women 49
4.2.6 Women are 1.5 times more likely to develop AD than men 50
4.2.7 Depression triples the risk for AD, and is the most common comorbidity 50
4.2.8 Up to 70% of AD patients also suffer from anxiety 51
4.2.9 Psychosis and agitation are common comorbidities in Alzheimer’s patients 51
4.3 Global Trends 51
4.3.1 US 52
4.3.2 5EU 53
4.3.3 Japan 55
4.3.4 China 56
4.3.5 India 56
4.4 Forecast Methodology 57
4.4.1 Sources Used 62
4.4.2 Forecast Assumptions and Methods 69
4.4.3 Sources Not Used 79
4.5 Epidemiology Forecast (2013-2023) 81
4.5.1 Total Prevalent Cases of AD 81
4.5.2 Age-Specific Total Prevalent Cases of AD 83
4.5.3 Sex-Specific Total Prevalent Cases of AD 85
4.5.4 Age-Standardized Total Prevalence of AD 88
4.5.5 Total Prevalent Cases of AD, by Severity 89
4.5.6 Total Prevalent Cases of MCI 91
4.5.7 Age-Specific Total Prevalent Cases of MCI 93
4.5.8 Sex-Specific Total Prevalent Cases of MCI 95
4.5.9 Age-Standardized Total Prevalence of MCI 98
4.6 Discussion 99
4.6.1 Conclusions Regarding the Epidemiological Trends 99
4.6.2 Limitations of the Analysis 101
4.6.3 Strengths of the Analysis 102
5 Disease Management 103
5.1 Diagnosis Overview 103
5.1.1 Probable AD Dementia 106
5.1.2 Preclinical AD 107
5.1.3 MCI 108
5.2 Treatment Overview 110
5.3 Clinical Practice 112
5.3.1 Leading Prescribed Therapies 114
5.4 US 115
5.5 France 118
5.6 Germany 120
5.7 Italy 122
5.8 Spain 124
5.9 UK 126
5.10 Japan 129
5.11 China 131
5.12 India 133
6 Competitive Assessment 135
6.1 Overview 135
6.2 Product Profiles – Major Brands 136
6.2.1 Aricept (donepezil hydrochloride) 136
6.2.2 Exelon (rivastigmine, rivastigmine tartrate) 141
6.2.3 Razadyne (galantamine hydrobromide) 146
6.2.4 Namenda (memantine hydrochloride) 151
6.3 Other Drugs/Classes 157
7 Unmet Need and Opportunity 159
7.1 Overview 159
7.2 Drugs with Disease-Modifying Mechanisms of Action 160
7.2.1 Unmet Need 160
7.2.2 Gap Analysis 161
7.2.3 Opportunity 162
7.3 Diagnosis in the Prodromal or Presymptomatic Stages 163
7.3.1 Unmet Need 163
7.3.2 Gap Analysis 164
7.3.3 Opportunity 165
7.4 Improved Control of Symptoms 166
7.4.1 Unmet Need 166
7.4.2 Gap Analysis 167
7.4.3 Opportunity 168
7.5 Easier Access to Treatment 169
7.5.1 Unmet Need 169
7.5.2 Gap Analysis 169
7.5.3 Opportunity 170
8 Pipeline Assessment 172
8.1 Overview 172
8.2 Clinical Trial Mapping 173
8.2.1 Clinical Trials by Class 173
8.3 Promising Drugs in Clinical Development 174
8.3.1 Biopharmaceutical Products 176
8.3.2 Small Molecule 209
8.3.3 Other Drugs in Development 258
9 Current and Future Players 260
9.1 Overview 260
9.2 Trends in Corporate Strategy 261
9.3 Company Profiles 262
9.3.1 Actavis 262
9.3.2 Lundbeck 265
9.3.3 Eisai 268
9.3.4 Pfizer 270
9.3.5 Novartis 272
9.3.6 Roche 274
9.3.7 Eli Lilly 276
9.3.8 Merck & Co. 280
9.3.9 AstraZeneca 281
9.3.10 Takeda 283
10 Market Outlook 286
10.1 Global Markets 286
10.1.1 Forecast 286
10.1.2 Drivers and Barriers – Global Issues 294
10.2 United States 297
10.2.1 Forecast 297
10.2.2 Key Events 301
10.2.3 Drivers and Barriers 302
10.3 France 305
10.3.1 Forecast 305
10.3.2 Key Events 308
10.3.3 Drivers and Barriers 309
10.4 Germany 312
10.4.1 Forecast 312
10.4.2 Key Events 315
10.4.3 Drivers and Barriers 315
10.5 Italy 317
10.5.1 Forecast 317
10.5.2 Key Events 321
10.5.3 Drivers and Barriers 321
10.6 Spain 323
10.6.1 Forecast 323
10.6.2 Key Events 327
10.6.3 Drivers and Barriers 327
10.7 United Kingdom 329
10.7.1 Forecast 329
10.7.2 Key Events 332
10.7.3 Drivers and Barriers 333
10.8 Japan 335
10.8.1 Forecast 335
10.8.2 Key Events 339
10.8.3 Drivers and Barriers 339
10.9 China 341
10.9.1 Forecast 341
10.9.2 Key Events 345
10.9.3 Drivers and Barriers 345
10.10 India 347
10.10.1 Forecast 347
10.10.2 Key Events 350
10.10.3 Drivers and Barriers 350
11 Appendix 353
11.1 Bibliography 353
11.2 Abbreviations 378
11.3 Methodology 388
11.4 Forecasting Methodology 388
11.4.1 Diagnosed AD Patients 388
11.4.2 Percent Drug-Treated Patients 389
11.4.3 Drugs Included in Each Therapeutic Class 389
11.4.4 Launch and Patent Expiry Dates 390
11.4.5 General Pricing Assumptions 391
11.4.6 Compliance Assumptions 392
11.4.7 Individual Drug Assumptions 394
11.4.8 Generic Erosion 400
11.4.9 Pricing of Pipeline Agents 400
11.5 Primary Research – KOLs Interviewed for This Report 402
11.6 Primary Research – Prescriber Survey 403
11.7 About the Authors 404
11.7.1 Analyst 404
11.7.2 Therapy Area Director 404
11.7.3 Epidemiologist 405
11.7.4 Global Head of Healthcare 405
11.8 About GlobalData 406
11.9 Disclaimer 406
【レポート販売概要】
■ タイトル:アルツハイマー病治療薬の世界市場予測および分析■ 英文:PharmaPoint: Alzheimer’s Disease - Global Drug Forecast and Market Analysis to 2023 - Event-Driven Update
■ 発行日:2015年5月1日
■ 調査会社:GlobalData
■ 商品コード:GDHC010EPIDR
■ 調査対象地域:グローバル
- Unit Corporation:石油・ガスの開発・生産動向及びコスト分析- Q2, 2013Unit Corporation Oil & Gas Exploration and Production Operations and Cost Analysis - Q2, 2013 Summary Unit Corporation Oil & Gas Exploration and Production Operations and Cost Analysis is the latest report from GlobalData, the industry analysis specialists, that offers comprehensive information on the operational and financial performance of the company. The report is an essential source for key o …
- 農業用フィルムの世界市場予測(~2021年):LLDPEフィルム、LDPEフィルム、再生フィルム、EVAフィルム、HDPEフィルム、ハウス用フィルム、除草用フィルム、サイレージフィルムThe global market size of agricultural films was USD 9.13 Billion in 2016, and is projected to reach USD 12.51 Billion by 2021, registering a CAGR of 6.5% during the forecast period. Global focus on increasing agricultural output and increasing demand of agricultural films from the dairy industry is expected drive the market during the forecast period. The agricultural films market is classified o …
- 世界のロタウイルス検査市場The report presents a detailed analysis of the Rotavirus diagnostics market in the US, Europe (France, Germany, Italy, Spain, UK) and Japan. Current scientific views on the Rotavirus definition, epidemiology and etiology are reviewed. The report provides the 5-year test volume and sales forecasts by country for the following market segments: - Hospitals - Comm …
- 業務用包丁の世界市場2019-2023111 pages, November 2018 About this market The emergence of newer materials in the manufacturing of commercial kitchen knives is proving to be advantageous for companies in the process of product development. Of all, one such new material that’s gaining popularity and being used widely to manufacture kitchen knives is powdered steel, that improves the sharpness of the blade. The method is called p …
- 冷凍機(チラー)の世界市場:スクリュー冷凍機、スクロール冷凍機、遠心冷凍機、吸収式冷凍機、往復式冷凍機The global chillers market size is estimated to reach USD 10.84 Billion by 2021 at a CAGR of 4.24%. The chillers market is driven by the increasing process cooling needs in industrial applications and stringent environmental regulations driving the demand for chillers. Moreover, factors such as increasing population and rising consumption of frozen food are also contributing significantly to the i …
- MDU Resources Group, Inc.:石油・ガスの開発・生産動向及びコスト分析– Q4, 2012MDU Resources Group, Inc. Oil & Gas Exploration and Production Operations and Cost Analysis – Q4, 2012 Summary MDU Resources Group, Inc. Oil & Gas Exploration and Production Operations and Cost Analysis is the latest report from GlobalData, the industry analysis specialists, that offers comprehensive information on the operational and financial performance of the company. The report is an essentia …
- 断熱ガラスの世界市場分析:用途別(非住宅建設、住宅建設、工業)、地域別(北アメリカ、ヨーロッパ、アジア太平洋、中南米、中東、アフリカ)、セグメント予測、2014-2025The global insulating glass market is expected to reach USD 4.26 billion by 2025, according to a new report by Grand View Research, Inc. The rising awareness about energy efficient buildings is expected to drive demand for insulating glass. Insulating glass is a special type of value added product which is installed to keep the environment warmer in winters and cooler during the summer season. The …
- 世界のエネルギーマネジメントシステム(EMS)市場Energy Management System (EMS) is a turnkey solution comprising software and related hardware along with communication systems for various challenges faced by energy utilities in managing critical transmission and generation infrastructure. Energy utilities across the globe are under pressure to put off costly capital expenditures by reducing operational costs and enhance utilization of existing i …
- 世界のジェネリック医薬品(後発医薬品)市場動向(2014-2018)TechNavio's analysts forecast the Global Generic Drugs market to grow at a CAGR of 11.02 percent over the period 2013-2018. The patent expiry of top-selling drugs is one of the major drivers contributing to the growth of this market. The market is also witnessing an increase in mergers and acquistions. However, intense competition among vendors could squeeze profit margins, increase pricing pressu …
- 世界のハイスループットスクリーニング(高速大量スクリーニング)市場動向及び予測(~2018)“Technological Advancements and Flourishing Outsourcing Industry Likely to Propel the Growth of the Global High Throughput Screening (HTS) Market” In this report, the global high throughput screening (HTS) market has been segmented on the basis of technology, products, applications, end users, and geography. The label-free technology market is expected to grow at the highest CAGR of 11.1% from 201 …
- 自動車ウィンドウ及び外部シーリングシステムの世界市場The automotive window and exterior sealing systems has witnessed considerable growth in emerging economies such as China, India, and Mexico, due to technological advancement and increasing vehicle production. This report classifies and defines the global automotive window and exterior sealing systems market size, in terms of volume and value. Market size, in terms of volume, is provided in thousan …
- 多発性硬化症治療薬の世界市場2019-2023About this market Globally, the prevalence of multiple sclerosis has increased due to genetic and environmental factors. Another reason which could be attributed to the increasing prevalence is the advances in diagnostic techniques in this therapy area. The prevalence of autoimmune diseases such as type 1 diabetes and certain infections such as infectious mononucleosis also increases the risk of m …
- 小型リチウムイオン電池の世界市場2015-2019About Li-ion Batteries A small Li-ion battery is a rechargeable battery that is commonly used for portable applications such as mobile phones, laptops, tablets, e-cigarettes, power tools, e-bikes, and digital cameras. The advantages of small Li-ion batteries, such as their compact size, light weight, high power, and high capacity have made them increasingly popular across industries such as consum …
- 事業提携・ライセンシング・投資・M&A動向:February 2013(製薬業界)Partnerships, Licensing, Investments and M&A Deals and Trends for February 2013 in Pharmaceuticals Summary GlobalData's “Partnerships, Licensing, Investments and M&A Deals and Trends for February 2013 in Pharmaceuticals” report is an essential source of data and trend analysis on partnerships, licensing, mergers and acquisitions (M&As) and financings in the pharmaceuticals industry. The report pro …
- 民間航空機用健全性監視システム(AHMS)の世界市場ABSTRACTAbout Commercial Aircraft Health Monitoring Systems Aircraft health monitoring systems (AHMS) collect data in real time from the aircraft fleet and make it available to ground operations. Various sensors are installed at various damage hotspots throughout aircraft structure/engine, which provide an early detection of anomaly (or initiation of crack/fatigue). Thus, necessary preventive meas …