【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 9
1.1 List of Tables 13
1.2 List of Figures 15
2 Introduction 17
2.1 Catalyst 17
2.2 Related Reports 17
2.3 Upcoming Related Reports 17
3 Disease Overview 18
3.1 Etiology and Pathophysiology 18
3.1.1 Pathophysiology of Indolent and Aggressive B-Cell NHL 19
3.2 Symptoms 23
4 Disease Management 24
4.1 Diagnosis 24
4.1.1 Diagnostic Classification 25
4.2 Treatment Overview 27
5 Epidemiology 33
5.1 Disease Background 33
5.2 Risk Factors and Comorbidities 33
5.3 Global Trends 35
5.3.1 US 36
5.3.2 US 36
5.3.3 5EU 37
5.4 Forecast Methodology 40
5.4.1 Sources Used 42
5.4.2 Forecast Assumptions and Methods 44
5.4.3 Age-Standardized Incidence Rates 48
5.5 Epidemiological Forecast for B-Cell NHL (2013-2023) 48
5.5.1 Follicular Lymphoma 48
5.5.2 Marginal Zone Lymphoma 54
5.5.3 DLBCL 59
5.5.4 Mantle Cell Lymphoma 64
5.6 Discussion 71
5.6.1 Epidemiological Forecast Insight 71
5.6.2 Limitations of the Analysis 72
5.6.3 Strengths of the Analysis 73
6 Current Treatment Options 74
6.1 Overview 74
6.2 Product Profiles – Major Brands, Follicular Lymphoma 76
6.2.1 Imbruvica (ibrutinib) 76
6.2.2 Revlimid (lenalidomide) 80
6.2.3 Rituxan/MabThera (rituximab) 85
6.2.4 Treanda (bendamustine) 91
6.2.5 Velcade (bortezomib) 93
6.2.6 Zevalin (ibritumomab tiuxetan) 96
6.2.7 Zydelig (idelalisib, GS-1101, CAL-101) 100
7 Unmet Needs Assessment and Opportunity Analysis 104
7.1 Overview 104
7.2 Unmet Needs Analysis 104
7.2.1 Unmet Need: Safe and Tolerable Front-Line Agents for Indolent NHL Patients that Prolong OS and Delay Relapse 104
7.2.2 Unmet Need: Prolonged Survival Rates for Mantle Cell Patients 105
7.2.3 Unmet Need: Improved Cure Rate for DLBCL Patients after Front-Line Therapy 105
7.2.4 Unmet Need: Predictive and Prognostic Molecular Biomarkers 106
7.3 Opportunity Analysis 107
7.3.1 Opportunity: More Cost-Effective Therapies 107
7.3.2 Opportunity: Better Consolidation/Maintenance Therapies for Follicular Patients 107
7.3.3 Novel Agents for Front-Line DLBCL and Mantle Cell Lymphoma Therapy 108
8 R&D Strategies 109
8.1 Overview 109
8.1.1 Targeting Multiple NHL Subtypes and Lines of Therapy to Capture Greatest Patient Share 110
8.1.2 Inhibiting New Targets in Relapsed/Refractory NHL Patients 111
8.1.3 Developing Novel Drugs in Combination with Rituxan/MabThera to Replace Chemoimmunotherapy Regimens 112
8.1.4 Franchise Management through Developing Novel Second-Generation Therapies to Replace Established Standards of Care at the End of Their Patent Life 112
8.1.5 Small Biotechs Collaborating on Investigator-Sponsored Early-Stage Trials to De-Risk Later-Stage Studies 113
8.1.6 Introducing New Routes of Drug Delivery to Improve Patient Convenience 114
8.2 Clinical Trial Design 115
8.2.1 Indolent B-Cell NHL 115
8.2.2 Aggressive B-Cell NHL 117
8.2.3 Clinical Endpoints 118
8.2.4 Comparator Arms 119
9 Pipeline Assessment 121
9.1 Overview 121
9.2 Promising Drugs in Clinical Development 121
9.2.1 Arzerra (ofatumumab) 122
9.2.2 Gazyva (obinutuzumab) 125
9.3 Innovative Early-Stage Approaches 130
9.3.1 Adcetris (brentuximab vedotin) 132
9.3.2 Alisertib (MLN8237) 132
9.3.3 Blinatumomab (AMG-101) 133
9.3.4 Copanlisib (BAY 80-6946) 133
9.3.5 Y-90 Epratuzumab 134
9.3.6 Chimeric Antigen Receptor T-Cell Therapies 135
10 Pipeline Valuation Analysis 136
10.1 Clinical Benchmark of Key Pipeline Drugs 136
10.2 Commercial Benchmark of Key Pipeline Drugs 139
10.3 Competitive Assessment 140
10.4 Top Line Five Year Forecast 142
10.4.1 US 144
10.4.2 5EU 145
11 Appendix 146
11.1 Bibliography 146
11.2 Abbreviations 162
11.3 Methodology 168
11.4 Forecasting Methodology 168
11.4.1 Diagnosed NHL patients 168
11.4.2 Percent Drug-Treated Patients 168
11.4.3 Drugs Included in Each Therapeutic Class 169
11.4.4 Launch and Patent Expiry Dates 169
11.4.5 General Pricing Assumptions 170
11.4.6 Individual Drug Assumptions 170
11.4.7 Generic Erosion 173
11.4.8 Pricing of Pipeline agents 173
11.5 Physicians and Specialists Included in This Study 174
11.6 Survey of Prescribing Physicians 174
11.7 About the Authors 175
11.7.1 Authors 175
11.7.2 Epidemiologist 176
11.7.3 Global Head of Healthcare 176
11.8 About GlobalData 177
11.9 Disclaimer 177
【レポート販売概要】
■ タイトル：非ホジキンリンパ腫（B細胞リンパ腫）：市場機会及び予測（～2018）■ 英文：OpportunityAnalyzer: Non-Hodgkin’s B-Cell Lymphoma - Opportunity Analysis and Forecast to 2018
■ 発行日：2014年8月25日
■ 調査会社：GlobalData
■ 商品コード：GDHC035POA
■ 調査対象地域：グローバル
- 成人用おむつの中東・アフリカ市場2019-2023About this marketThe rise in innovative product offerings is one of the key factors expected to trigger the adult diapers market growth in MEA during the forecast period. Product innovations are leading to the development of comfortable, thin adult diapers, convenient diapers with excessive retention capacity and increased fluid absorption. Vendors are also introducing several innovative designs o …
- 世界の粉体塗装(パウダーコーティング)市場（2014-2018）About Powder Coatings Powder coatings are a type of solvent-free coating product used to provide a dry finishing process. They They are known to provide a high-quality, durable finish. Moreover, they emit minimal volatile organic compounds and are therefore eco-friendly compared to solvent-based coatings. Powder coatings are composed of resins, additives, curing agents, extenders or fillers, and t …
- ジオシンセティックスの世界市場：インサイト、市場機会、市場シェア、市場予測Geosynthetics materials are defined as polymeric materials used for engineering applications like civil construction and environmental protection projects (landfills). Generally, the materials used for the productions of Geosynthetics are polypropylene, polyethylene, and polyester. Based on their physical characteristics and related applications, they are categorized into geotextiles, geogrids, ge …
- 世界の電子産業におけるナノ技術及びナノ材料市場This 240 page report from Future Markets, Inc. covers the raft of applications and end products enabled by nanotechnology and nanomaterials in the electronics sector. Report contents include technology development in the electronics sector utilizing the following materials: Nanoparticles Carbon nanotubes Fullerenes and POSS Graphene Nanofibers Nanosilver Nanowires Nanobuds Quantum dots 2-D Nanomat …
- 世界の薄層堆積装置市場2015The Global Thin Layer Deposition Equipment Industry 2015 Market Research Report is a professional and in-depth study on the current state of the Thin Layer Deposition Equipment industry. The report provides a basic overview of the industry including definitions, classifications, applications and industry chain structure.The Thin Layer Deposition Equipment market analysis is provided for the intern …
- カナダの滅菌器市場見通し（～2021）Canada Sterilization Equipment Market Outlook to 2021 Summary GlobalData’s new report, "Canada Sterilization Equipment Market Outlook to 2021", provides key market data on the Canada Sterilization Equipment market. The report provides value, in millions of US dollars, volume (in units) and average price data (in US dollars), within market segments - Chemical Sterilizers, Physical Sterilizers and U …
- 帯状疱疹ワクチン（Herpes Zoster vaccine）の世界市場機会分析Varicella-zoster virus is a ubiquitous human alphaherpesvirus, which after infection in childhood causes a relatively mild self-limiting illness. However, if the virus becomes reactivated later on in life it can cause a painful rash (shingles), often leading to postherpetic neuralgia (PHN). PHN has a significant economic burden because patients require systemic anti-viral therapy and pain manageme …
- 世界の骨粗しょう症治療・予防市場予測：抗嘔吐薬、骨粗しょう症治療薬、再吸収阻害薬、同化薬Osteoporosis drugs – new study showing you trends, R&D progress, and predicted revenues Where’s the osteoporosis drugs market heading? Visiongain’s brand new report shows you potential revenues to 2024, assessing data, trends, opportunities and prospects there. Our 217-page report provides 132 tables, charts, and graphs. Discover the most lucrative areas in the industry and the future market prosp …
- 医療産業における認知評価・トレーニングの世界市場予測（～2021年）MarketsandMarkets forecasts the cognitive assessment and training in healthcare market size to grow from USD 962.0 Million in 2016 to USD 4,127.2 Million by 2021, at a Compound Annual Growth Rate (CAGR) of 33.8%. Major factors contributing to the growth of the market include aging global population, increasing awareness about brain fitness, and advancements in technology. These factors will drive …
- 民間ヘリコプターの世界市場予測2015-2025Civil helicopters extend the reach and expand the capabilities of businesses, governments and security agencies. The positive impact of civil helicopters for entities that can afford to acquire and operate them remains compelling. However, purchases must also be weighed against the prevailing economic conditions. For decades, the civil helicopter market was one of the smallest segments in the aero …
- 世界の半導体スピンスプレープロセッサー装備市場（2014-2018）TechNavio’s analysts forecast the Global Semiconductor Spin Spray Processor Equipment market will grow at a CAGR of 2.31 percent over the period 2013-2018. One of the key factors contributing to this market growth is the increasing demand for the integration and miniaturization of semiconductor devices. The Global Semiconductor Spin Spray Processor Equipment market has also been witnessing the eme …
- 世界のクラウド基盤ITサービスマネジメント（ITSM）市場動向（2014～2018）TechNavio's analysts forecast the Global Cloud-based ITSM market to grow at a CAGR of 16.82 percent over the period 2013-2018. One of the key factors contributing to this market growth is the increasing demand for economical ITSM solutions. The Global Cloud-based ITSM market has also been witnessing the increasing use of personal devices in the workplace. However, the integration concerns with exi …
- オーストリアの風力発電産業分析：Analyzing the Wind Power Industry in AustriaAs demand on finite petroleum reserves and the price of the fuels derived from them continues to rise, renewable forms of energy are becoming more cost-effective and profitable. In the forefront of this renewable revolution is harnessing the sustainable power of wind. Today it is one of the most positive developments created by the present storm of uncertainty unleashed as a result of escalating o …
- 軍事通信の世界市場Armed forces throughout the globe rely on communication systems to enable information sharing and securely stay in constant contact. The role of these systems continues to grow in importance, with new mission areas such as the control of unmanned vehicles and time-critical targeting heavily reliant on network connectivity. Despite pressures on overall defense expenditure, a universal trend towards …
- 学習分析（ラーニングアナリティクス）の世界市場2015-2019About learning analytical tools BI and analytics platforms cover all BI and analytics solutions that are deployed within organizations. Learning analytics software uses tools and applications for collecting, managing, and analysing both structured and unstructured data to improve multiple processes and activities. The learning analytical tools include content analytics, adaptive learning analytics …
