世界主要国におけるB型肝炎治療薬市場...市場調査レポートについてご紹介

1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 Classification 9
2.2 Pathophysiology 9
2.3 Etiology 11
2.4 Symptoms 12
2.5 Diagnosis 12
2.6 Epidemiology 13
2.7 Treatment and Management 15
2.8 Prognosis 16
2.9 Co-infection 17
2.9.1 HBV-HIV Co-infection 17
2.9.2 HBV-HDV Co-infection 17
2.9.3 HBV-HCV Co-infection 17
3 Marketed Products 18
3.1 Viread 18
3.1.1 Study 0102 18
3.1.2 Study 0103 18
3.2 Entecavir 19
3.2.1 Nucleoside-Inhibitor-Naive Subjects with Compensated Liver Disease (Studies AI463022 and AI463027) 20
3.2.2 Lamivudine-Refractory Subjects with Compensated Liver Disease (Study AI463026) 21
3.3 Pegasys (peg interferon α-2a) 23
3.4 Adefovir dipivoxil 25
3.4.1 Study 437 (HBeAg-Positive Chronic Hepatitis B Patients) 25
3.4.2 Study 438 (HBeAg-Negative Chronic Hepatitis B Patients) 25
3.4.3 Adefovir Treatment beyond 48 Weeks 27
3.4.4 Study 435 (Pre- and Post-liver Transplantation Subjects) 27
3.4.5 Study 461 (Clinical Evidence of Lamivudine Resistance Patients) 27
3.5 Tyzeka per Sebivo 28
3.5.1 NV-02B-007 GLOBE Trial 28
3.5.2 HBeAg-Positive Subjects 28
3.5.3 HBeAg-Negative Subjects 28
3.6 Comparative Efficacy and Safety 30
4 Pipeline Analysis 32
4.1 Overall Pipeline 32
4.2 Pipeline Analysis of Therapeutic Vaccines 33
4.3 Clinical Trials 35
4.3.1 Failure Rate 35
4.3.2 Failure Rate by Molecule Type 35
4.3.3 Failure Rate by Mechanism of Action 36
4.3.4 Patient Enrollment and Clinical Trial Size by Molecule Type 37
4.3.5 Duration 38
4.4 Competitive Clinical Trials Metrics Analysis 40
4.5 Promising Drug Candidates in Pipeline 40
4.5.1 GS-7340 (tenofovir alafenamide fumarate) 40
4.6 Therapeutic Vaccines in Pipeline 41
4.6.1 GS-4774 Therapeutic Vaccine with Oral Antiviral Treatment 41
4.6.2 ABX203 Therapeutic Vaccine with Nucleos(t)ide Analogs against HBeAg-Negative Chronic Hepatitis B 41
4.6.3 HB-110E Therapeutic DNA Vaccine 41
4.6.4 INO-1800 with or without INO-9112 in Entecavir/Tenofovir-Treated HBeAg-Positive Chronic Hepatitis B Patients 42
4.6.5 TG1050 Therapeutic Vaccine 43
5 Market Forecast to 2021 44
5.1 Geographical Markets 44
5.2 Global Market 44
5.3 North America 45
5.3.1 Treatment Usage Patterns 45
5.3.2 Annual Cost of Therapy 46
5.3.3 Market Size 47
5.4 Top Five EU Markets 48
5.4.1 Treatment Usage Patterns 48
5.4.2 Annual Cost of Therapy 49
5.4.3 Market Size 50
5.5 Japan 51
5.5.1 Treatment Usage Patterns 51
5.5.2 Annual Cost of Therapy 52
5.5.3 Market Size 53
5.6 Drivers and Barriers in the Disease Market 53
5.6.1 Drivers 53
5.6.2 Barriers 54
6 Deals and Strategic Consolidations 56
6.1 Licensing Deals 56
6.1.1 OnCore Enters into Licensing Agreement with NeuroVive 59
6.1.2 Ligand Enters into Licensing Agreement with Chiva for Pradefovir and MB01733 59
6.2 Co-development Deals 59
7 Appendix 61
7.1 All Pipeline Drugs by Phase of Development 61
7.1.1 Discovery 61
7.1.2 Preclinical 62
7.1.3 Phase I 63
7.1.4 Phase II 64
7.1.5 Phase III 64
7.2 Market Forecasts to 2021 65
7.2.1 Global 65
7.2.2 US 65
7.2.3 Canada 66
7.2.4 UK 66
7.2.5 France 67
7.2.6 Germany 67
7.2.7 Italy 68
7.2.8 Spain 68
7.2.9 Japan 69
7.3 Bibliography 69
7.4 Abbreviations 73
7.5 Research Methodology 74
7.5.1 Secondary Research 74
7.5.2 Marketed Product Profiles 75
7.5.3 Late-Stage Pipeline Candidates 75
7.5.4 Comparative Efficacy and Safety Heat Map for Marketed and Pipeline Products 75
7.5.5 Forecasting Model 76
7.5.6 Deals Data Analysis 77
7.6 Expert Panel Validation 78
7.7 Contact Us 78
7.8 Disclaimer 78