膵臓癌治療薬の世界市場：画期的医薬品の市場機会及び商用化...市場調査レポートについてご紹介

1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 3

2 Executive Summary 4
2.1 Large and Diverse Pipeline Contrasts the Limited Market 4
2.2 Pancreatic Cancer Shows High Levels of First-in-Class Innovation 4
2.3 High Deal Activity Reflects Dynamic Pipeline 4

3 The Case for Innovation 5
3.1 Growing Opportunities for Biologic Products 6
3.2 Diversification of Molecular Targets 6
3.3 Innovative First-in-Class Product Developments Remain Attractive 6
3.4 Regulatory and Reimbursement Policy Shifts Favor First-in-Class Product Innovation 7
3.5 Sustained Innovation 7
3.6 GBI Research Report Guidance 8

4 Clinical and Commercial Landscape 9
4.1 Disease Overview 9
4.2 Disease Symptoms 9
4.3 Epidemiology 9
4.4 Etiology 10
4.4.1 Risk Factors 10
4.4.2 Medical Conditions Leading to Pancreatic Cancer 10
4.4.3 Genetic Conditions Leading to Pancreatic Cancer 10
4.4.4 Conclusion 11
4.5 Pathophysiology 11
4.5.1 Frequently Dysregulated Pathways 11
4.5.2 Oncogenes 12
4.5.3 Tumor Suppressor Genes 13
4.6 Diagnosis 13
4.7 Prognosis 14
4.8 Treatment Options 14
4.8.1 Surgery 14
4.8.2 Radiation therapy 14
4.8.3 Chemotherapy 15
4.9 Chemotherapeutic Treatment Algorithm 16
4.9.1 Adjuvant Chemotherapy in Operable Early-Stage Disease 16
4.9.2 First-Line Treatment of Inoperable Advanced Disease 18
4.9.3 Second-Line Therapy in Inoperable Advanced Disease 25
4.10 Overview of Marketed Products in Pancreatic Cancer 26
4.10.1 Molecule Type and Target Analysis 26
4.10.2 Innovative Products in the Pancreatic Cancer Market 27
4.10.3 Unmet Needs 28

5 Assessment of Pipeline Product Innovation 29
5.1 Pancreatic Cancer Pipeline by Molecule Type, Phase and Therapeutic Target 29
5.2 Comparative Distribution of Programs between the Pancreatic Cancer Market and Pipeline by Therapeutic Target Family 34
5.3 First-in-Class Pipeline Programs Targeting Novel Molecular Targets 35

6 Signaling Network, Disease Causation and Innovation Alignment 41
6.1 The Complexity of Signaling Networks in Oncology 41
6.2 Signaling Pathways, Disease-Causing Mutations and First-in-Class Molecular Target Integration 42
6.3 First-in-Class Target Matrix Assessment 45

7 First-in-Class Target Evaluation 50
7.1 Pipeline Programs Targeting HER3 50
7.2 Pipeline Programs Targeting Akt2 and Akt3 52
7.3 Pipeline Programs Targeting P70-S6 Kinase 1 55
7.4 Pipeline Programs Targeting Prostaglandin E2 Receptor EP4 Subtype 56
7.5 Pipeline Programs Targeting Ghrelin Receptor 58
7.6 Pipeline Programs Targeting Neurotensin Receptor 1 60
7.7 Pipeline Programs Targeting CD40 61
7.8 Pipeline Programs Targeting High-Affinity Nerve Growth Factor Receptor 62
7.9 Pipeline Programs Targeting Protein Kinase C Alpha 64
7.10 Pipeline Programs Targeting MAP3K7 66
7.11 Conclusion 68

8 Deals and Strategic Consolidations 69
8.1 Industry-Wide First-in-Class Deals 69
8.2 Licensing Deals 70
8.2.1 Licensing Deals by Molecule Type 74
8.2.2 Licensing Deals by Molecular Target 75
8.3 Co-development Deals 76
8.3.1 Co-development Deals by Molecule Type 78
8.3.2 Co-development Deals by Molecular Target 79
8.4 First-in-Class Programs Not Involved in Licensing or Co-Development Deals 80

9 Appendix 84
9.1 References 84
9.2 Abbreviations 87
9.3 Contact Us 88
9.4 Disclaimer 88