【レポートの概要（一部）】
1 Table of Contents
1 Table of Contents 8
1.1 List of Tables 15
1.2 List of Figures 20
2 Introduction 22
2.1 Catalyst 22
2.2 Related Reports 23
2.3 Upcoming Related Reports 23
3 Disease Overview 24
3.1 Etiology and Pathophysiology 24
3.1.1 Etiology 24
3.1.2 Pathophysiology 25
3.1.3 Prognosis and Quality of Life 27
3.2 Symptoms 29
3.2.1 Hemophilia A and B 29
3.2.2 Inhibitors 30
4 Epidemiology 31
4.1 Disease Background 31
4.2 Risk Factors and Comorbidities 32
4.2.1 Almost 50% of hemophilia patients are affected by hypertension 33
4.3 Global Trends 34
4.4 Epidemiological Forecast of Hemophilia (2012-2022) 36
4.4.1 Forecast Methodology 36
4.4.2 Sources Used 37
4.4.3 Sources Not Used 38
4.4.4 Forecast Assumptions and Methods 38
4.5 Epidemiology Forecast (2012-2022), Hemophilia A 43
4.5.1 Diagnosed Prevalent Cases of Hemophilia A 43
4.5.2 Diagnosed Prevalent Cases of Hemophilia A by Age 45
4.5.3 Diagnosed Prevalent Cases of Hemophilia A by Sex 47
4.5.4 Age-Standardized Prevalence of Diagnosed Hemophilia A 48
4.6 Epidemiology Forecast (2012-2022), Hemophilia B 50
4.6.1 Diagnosed Prevalent Cases of Hemophilia B 50
4.6.2 Diagnosed Prevalent Cases of Hemophilia B by Age 52
4.6.3 Diagnosed Prevalent Cases of Hemophilia B by Sex 54
4.6.4 Age-Standardized Prevalence of Diagnosed Hemophilia B 56
4.7 Epidemiology Forecast (2012-2022), Hemophilia A and B 57
4.7.1 Diagnosed Prevalent Cases of Hemophilia A and B 57
4.7.2 Diagnosed Prevalent Cases of Hemophilia A and B by Sex 59
4.8 Discussion 61
4.8.1 Conclusions on Epidemiological Trends 61
4.8.2 Limitations of the Analysis 62
4.8.3 Strengths of the Analysis 63
5 Disease Management 64
5.1 Treatment Overview 64
5.1.1 Hemophilia A and B Diagnosis 65
5.1.2 Hemophilia A and B Treatment 65
5.1.3 Inhibitors Diagnosis 67
5.1.4 Inhibitors Treatment 67
5.2 US 69
5.2.1 Clinical Practice 69
5.3 France 72
5.3.1 Clinical Practice 72
5.4 Germany 74
5.4.1 Clinical Practice 74
5.5 Italy 76
5.5.1 Clinical Practice 76
5.6 Spain 78
5.6.1 Clinical Practice 78
5.7 UK 80
5.7.1 Clinical Practice 80
5.8 Japan 82
5.8.1 Clinical Practice 82
5.9 Argentina 84
5.9.1 Clinical Practice 84
5.10 China 86
5.10.1 Clinical Practice 86
6 Competitive Assessment 88
6.1 Overview 88
6.2 Strategic Competitive Assessment 89
6.3 Product Profiles – Major Brands, Hemophilia A 93
6.3.1 Advate (octocog alfa; Antihemophilic Factor [Recombinant] Plasma/Albumin-Free) 93
6.3.2 Kogenate FS/Helixate FS (Antihemophilic Factor (Recombinant)) 98
6.3.3 Xyntha/ReFacto AF (moroctocog alfa; Antihemophilic Factor [Recombinant], Plasma/Albumin-Free) 103
6.3.4 Recombinate (octocog alfa; Antihemophilic Factor [Recombinant] Plasma/Albumin-Free) 107
6.4 Product Profiles – Hemophilia B 110
6.4.1 BeneFIX (nonacog alfa; coagulation factor IX [recombinant]) 110
6.4.2 Rixubis (BAX-326) 115
6.5 Product Profiles – Hemophilia A and B with Inhibitors 120
6.5.1 NovoSeven RT (coagulation factor VIIa [recombinant]) 120
7 Opportunity and Unmet Need 123
7.1 Overview 123
7.2 Opportunities Analysis 124
7.2.1 Longer-Lasting Recombinant Factors to Reduce the Frequency of Prophylactic Injections 124
7.2.2 Lower-Cost Recombinant Replacement Therapies 125
7.2.3 Lower Risk of Inhibitor Formation in Previously Untreated Patients 126
7.2.4 More Convenient Drug Administration 126
7.2.5 Oral Formulation of Recombinant Replacement Therapies 127
7.3 Unmet Needs Gap Analysis 128
7.3.1 Long-Acting FVIII Replacement Therapies 128
7.3.2 Gene Therapy Treatments for Hemophilia A and B 128
8 Pipeline Assessment 129
8.1 Overview 129
8.2 Clinical Trial Mapping 129
8.2.1 Clinical Trials by Country 129
8.3 Clinical Trials by Phase and Trial Status 130
8.4 Promising Drugs in Clinical Development – Hemophilia A 131
8.4.1 Eloctate (rFVIII-Fc) (recombinant factor VIII fusion protein) 133
8.4.2 BAY 94-9027 (octocog alfa) 140
8.4.3 BAX-855 145
8.4.4 Novoeight (turoctocog alfa; NN7008) 150
8.4.5 N8-GP (NN7088) 155
8.4.6 CSL-627 (rFVIII-SC) 160
8.4.7 Hcl-rhFVIII 165
8.5 Promising Drugs in Clinical Development – Hemophilia B 170
8.5.1 Alprolix (rFIXFc) 172
8.5.2 CSL-654 (rIX-FP) 177
8.5.3 N9-GP (NN-7999) 182
8.5.4 IB1001 (trenacog alfa) 187
8.6 Promising Drugs in Clinical Development – Hemophilia A and B Patients with Inhibitors 192
8.6.1 BAX-817 (rFVIIa BI) 192
9 Current and Future Players 197
9.1 Overview 197
9.2 Trends in Corporate Strategy 199
9.3 Company Profiles 200
9.3.1 Baxter 200
9.3.2 Biogen Idec 204
9.3.3 Novo Nordisk 206
9.3.4 CSL Behring 209
9.3.5 Bayer 210
9.3.6 Pfizer 212
10 Market Outlook 214
10.1 Global Markets 214
10.1.1 Forecast 214
10.1.2 Drivers and Barriers – Global Issues 218
10.2 US 221
10.2.1 Forecast 221
10.2.2 Key Events 225
10.2.3 Drivers and Barriers 225
10.3 France 228
10.3.1 Forecast 228
10.3.2 Key Events 231
10.3.3 Drivers and Barriers 231
10.4 Germany 233
10.4.1 Forecast 233
10.4.2 Key Events 236
10.4.3 Drivers and Barriers 236
10.5 Italy 238
10.5.1 Forecast 238
10.5.2 Key Events 241
10.5.3 Drivers and Barriers 241
10.6 Spain 243
10.6.1 Forecast 243
10.6.2 Key Events 246
10.6.3 Drivers and Barriers 246
10.7 UK 248
10.7.1 Forecast 248
10.7.2 Key Events 251
10.7.3 Drivers and Barriers 251
10.8 Japan 254
10.8.1 Forecast 254
10.8.2 Key Events 257
10.8.3 Drivers and Barriers 257
10.9 Argentina 259
10.9.1 Forecast 259
10.9.2 Key Events 263
10.9.3 Drivers and Barriers 263
10.10 China 266
10.10.1 Forecast 266
10.10.2 Key Events 269
10.10.3 Drivers and Barriers 269
11 Appendix 271
11.1 Bibliography 271
11.2 Abbreviations 287
11.3 Methodology 290
11.4 Forecasting Methodology 290
11.4.1 Diagnosed Hemophilia Patients 291
11.4.2 Percent Drug-Treated Patients 291
11.4.3 Drugs Included in Each Therapeutic Class 291
11.4.4 Launch and Patent Expiry Dates 292
11.4.5 General Pricing Assumptions 293
11.4.6 Individual Drug Assumptions 294
11.4.7 Pricing of Pipeline Agents 298
11.5 Physicians and Specialists Included in this Study 299
11.6 About the Authors 301
11.6.1 Authors 301
11.6.2 Epidemiologists 302
11.6.3 Global Head of Healthcare 303
11.7 About GlobalData 304
11.8 Disclaimer 304
【レポート販売概要】
■ タイトル：血友病A及びB：世界市場（医薬品市場予測及び分析～2022）■ 英文：PharmaPoint: Hemophilia A and B - Global Drug Forecast and Market Analysis to 2022
■ 発行日：2013年11月30日
■ 調査会社：GlobalData
■ 商品コード：GDATA403162999
■ 調査対象地域：グローバル
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